284 documents found, page 1 of 29
Pioneering wound care solutions: triaxial wet-spun fibers with bioactive agents...
Miranda, Catarina Alexandra Fortuna Santos; Marinho, Elina Margarida Ribeiro; Rocha, Diana; Silva, C.; Silva, Maria Manuela; Schlapp-Hackl, IngeFiber-based constructs have been produced as an alternative to conventional dressings for the treatment of chronic wounds (CWs), showing good tenability, high surface area and regulable porosity. A commonly used technique for processing such dressings is wet-spinning, which involves precipitating a polymer solution into a coagulation bath containing a non-solvent of that polymer. This process produces fibers wi...
Pioneering wound care solutions: triaxial wet-spun fibers with bioactive agents...
Miranda, Catarina Alexandra Fortuna Santos; Silva, Ana Francisca Gomes da; Evenou, Camille; Lamartine, Jérôme; Fromy, BerengereThe incidence of bacterial infections associated with chronic wounds (CWs) has increased in recent years. Thus, a triaxial wet-spun fibrous system (containing three layers) was produced for CW healing. The triaxial fibers were loaded with cinnamon leaf oil (CLO), endowed with high antibacterial, antioxidant and anti-inflammatory features, and an antimicrobial peptide alaninealanineprolinevaline (AAPV) capable o...
meso-Dimethylaminonaphthyl-BODIPY Derivatives as Bioimaging Probes to Monitor I...
Gonçalves, Raquel C. R.; Pinto, Sónia C.S.; Teixeira, Filipe; Belmonte-Reche, Efres; da Silva, Milene Costa; Gallo, Juan; Costa, Susana P. G.Fluorescence-based probes are a powerful tool for monitoring living systems in real time with spatiotemporal precision. 3-Difluoroborodipyrromethene (BODIPY) derivatives are widely used as bioimaging probes due to their excellent photophysical properties, high quantum yields, and chemical stability. In this context, we report two BODIPY-based fluorescent probes for visualizing lysosomes and lipid droplets as we...
Synthesis, photophysical and spectroscopic characterization of amphiphilic D-A-...
Boland, Mathilde; Pinto, Sónia; Gomes-da-Silva, Lígia C.; Pina, João; Costa, Susana P. G.; Raposo, M. Manuela M.Two positively charged amphiphilic benzothiadiazole derivatives with a Donor-Acceptor-π spacer-Acceptor structure (D-A-π-A) were developed, based on a methoxy-phenyl-benzothiadiazole model compound, by adopting methoxy-phenyl as the electron donor and 2,1,3-benzothiadiazole and 2,3-dimethylbenzothiazol-3-ium or 2,3-dimethylnaphtothiazol-3-ium iodide as combined electron acceptors. The aim of the study was to in...
Push-pull fluorophores based on NHS esters of bithiophene for labelling of biom...
Barros, Mariana; Arroyo, Pau; Sáez, Jose A.; Gil, Salvador; Parra, Margarita; Costa, Susana P. G.; Raposo, M. Manuela M.; Gaviña, PabloFluorescent labelling is a versatile tool to visualize biomolecules containing primary amines in their cellular environment, allowing the study of their function or interactions. Here, three organic fluorophores that can irreversibly bind to the primary amine group on the target biomolecule are reported. They consist of push-pull heterocyclic dyes based on bithiophene and incorporating a terminal N-hydroxysucci...
Quinoline-based hydrazones for biocide detection: Machine learning-aided design...
Sousa, Rui Pedro Carvalho Lima; Teixeira, Filipe; Costa, Susana P. G.; Figueira, Rita Bacelar; Raposo, M. Manuela M.Antifouling compounds are used as paint components to mitigate biofouling on ships and submerged structures. One of the most known and used antifouling compounds is tributyltin (TBT). However, TBT is toxic to aquatic living beings, causing problems such as reduction of growth and imposex. The development of a TBT chemosensor could be of utter relevance in the building of an in-situ TBT monitoring device. Theref...
Antimicrobial, antioxidant and cytocompatible coaxial wet-spun fibers made of p...
Miranda, Catarina S.; Marinho, Elina Margarida Ribeiro; Seabra, Catarina Leal; Evenou, Camille; Lamartine, Jérôme; Fromy, Berengere; Costa, Susana P. G.Chronic wounds represent a serious worldwide concern, being often associated with bacterial infections. As the prevalence of bacterial infections increase, it is crucial to search for alternatives. Essential oils (EOs) constitute a promising option to antibiotics due to their strong anti-inflammatory, analgesic, antioxidant and antibacterial properties. However, such compounds present high volatility. To addres...
Inhibition of enzyme and bacteria activities in diabetic ulcer-like scenarios v...
Ribeiro, Ana R. M.; Miranda, Catarina S.; Silva, Ana Francisca G.; Mendes, Filipa D. P.; Silva, Beatriz M.; Oliveira, Bruna A. S.; Paiva, Eduardo D.In diabetic ulcers, an increased secretion of human neutrophil elastase (HNE) and bacterial infections play crucial roles in hindering healing. Considering that, the present study proposed the development of multi-action polycaprolactone (PCL)/polyethylene glycol (PEG) electrospun fibers incorporating elastase-targeting peptides, AAPV and WAAPV, via blending. Characterization confirmed WAAPV’s efficacy in regul...
Designing Antitrypanosomal and Antileishmanial BODIPY Derivatives: A Computatio...
Gonçalves, Raquel C. R.; Teixeira, Filipe; Peñalver, Pablo; Costa, Susana P. G.; Morales, Juan C.; Raposo, M. Manuela M.Leishmaniasis and Human African trypanosomiasis pose significant public health threats in resource-limited regions, accentuated by the drawbacks of the current antiprotozoal treatments and the lack of approved vaccines. Considering the demand for novel therapeutic drugs, a series of BODIPY derivatives with several functionalizations at the meso, 2 and/or 6 positions of the core were synthesized and characterize...
Sustainable fluorescent dye-faujasite zeolite systems as tools for cancer bioim...
Bertão, Ana R.; Güney, Orhan; Costa, Marta; Fontão, Patrícia; Martinho, Olga; Costa, Susana P. G.; Fonseca, A. M.; Soares, Olívia S. G. P.The use of fluorescent nanoparticles for biological and medical applications has attracted great attention due to their several advantages compared to conventional fluorescent dyes. However, there is also a need for sustainable and versatile alternatives, alongside the streamlining of complex synthesis or preparations. In this work, we study the potential of the faujasite zeolite structure to encapsulate dye mo...