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An insight into the synthesis of cationic porphyrin-imidazole derivatives and t...
Moreira, Xavier; Santos, Patrícia; Faustino, M. Amparo F.; Raposo, M. Manuela M.; Costa, Susana P.G.; Moura, Nuno M.M.; Gomes, Ana T.P.C.New porphyrin-imidazole derivatives were synthesised by Radziszewski reaction between 2-formyl-5,10,15,20-tetraphenylporphyrin 1 and several (hetero)aromatic 1,2-diones, which after cationization afforded promising monocationic photosensitizers 3a-d. Singlet oxygen studies have demonstrated that all the cationic porphyrin-imidazole conjugates 3a–d were capable to produce cytotoxic species. These photosensitizer...
Date: 2020
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Origin: RIA - Repositório Institucional da Universidade de Aveiro