2 documents found, page 1 of 1
Cardiac mitochondrial dynamics, autophagy and regeneration are stirred by doxor...
Brandão, S. R.; Reis-Mendes, A.; Neuparth, M. J.; Carvalho, F.; Ferreira, R.; Costa, V. M.Background: The chemotherapeutic agent doxorubicin (DOX) has been widely used in the treatment of solid tumors and hematological malignancies [1]. However, serious adverse side effects have emerged in patients treated with this drug, notably cardiotoxicity [2]. Moreover, aging is a risk factor for the development of cardiovascular diseases in cancer treated patients [3]. Objective: We herein aimed to evaluate t...
The influence of glutathione pathway modulators on the cytotoxicity of sunitini...
Vitorino-Oliveira, C.; Kahremany, S.; Nisim, L.; Duarte-Araújo, M.; Carvalho, F.; Gruzman, A.; Costa, V. M.Background: Cancer survivorship has grown over the years due to more efficacious treatments. Nonetheless, anticancer treatments present serious adverse effects, namely cardiotoxicity. Doxorubicin (DOX), a topoisomerase II inhibitor; sunitinib (SUN), a multikinase inhibitor; and bortezomib (BTZ), an inhibitor of proteasome, have their clinical use limited because of their cardiotoxicity. Cardiotoxicity is often ...