2 documents found, page 1 of 1
Framework for clinical trials in cerebral small vessel disease (FINESSE)
Markus, Hugh S.; van Der Flier, Wiesje M.; Smith, Eric E.; Bath, Philip; Biessels, Geert Jan; Briceno, Emily; Brodtman, Amy; Chabriat, HuguesImportance: Cerebral small vessel disease (SVD) causes a quarter of strokes and is the most common pathology underlying vascular cognitive impairment and dementia. An important step to developing new treatments is better trial methodology. Disease mechanisms in SVD differ from other stroke etiologies; therefore, treatments need to be evaluated in cohorts in which SVD has been well characterized. Furthermore, SV...
Cognitive impairment in patients with cerebrovascular disease : a white paper f...
Verdelho, Ana; Wardlaw, Joanna; Pavlovic, Aleksandra; Pantoni, Leonardo; Godefroy, Olivier; Duering, Marco; Charidimou, Andreas; Chabriat, HuguesPurpose: Many daily-life clinical decisions in patients with cerebrovascular disease and cognitive impairment are complex. Evidence-based information sustaining these decisions is frequently lacking. The aim of this paper is to propose a practical clinical approach to cognitive impairments in patients with known cerebrovascular disease. Methods: The document was produced by the Dementia Committee of the Europea...