27 documents found, page 1 of 3

Assessing the cytotoxic effects of sunitinib on AC16 cardiac cells and its pote...

Background: Cancer survivorship rate has witnessed a notable increase, leveraged by amazing therapeutic advancements. However, these treatments have limitations and problems. Sunitinib (SUN) is a multikinase inhibitor, used in renal cell carcinoma and gastrointestinal stromal tumors. However, its use is limited due to cardiotoxicity, among other adverse effects. Therefore, it is important to understand the mech...

Oral methylphenidate effects on GAP43 and PSD95 expression in the developing br...

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent neuropsychiatric disorder in childhood and adolescence [1]. Differences in brain structure, function, and connectivity were seen between ADHD and healthy individuals [2,3] but the underlying cellular and neurobiological mechanisms of ADHD are not fully understood [3,4]. Objective: To evaluate how clinically relevant oral doses of methylp...

Comparing Cytotoxic Effects of Synthetic Cathinones and Methamphetamine on Card...

Background Synthetic cathinones are psychoactive derivatives of the natural drug cathinone. Despite being sold as safer than traditional drugs, over the years there has been a rise in fatalities associated with the cardiotoxic effects of synthetic cathinones [1]. Still, few studies address the mechanisms underlying this toxicity. Objective: This work aimed to study the cardiotoxicity of synthetic cathinones (me...

Biomarkers of NRF2 signalling: Current status and future challenges

The cytoprotective transcription factor NRF2 regulates the expression of several hundred genes in mammalian cells and is a promising therapeutic target in a number of diseases associated with oxidative stress and inflammation. Hence, an ability to monitor basal and inducible NRF2 signalling is vital for mechanistic understanding in translational studies. Due to some caveats related to the direct measurement of ...

Biodistribution and intestinal inflammatory response following voluntary oral i...

Silver nanoparticles (AgNP) are among the most widely commercialized nanomaterials globally, with applications in medicine and the food industry. Consequently, the increased use of AgNP in the food industry has led to an unavoidable rise  in human exposure to these nanoparticles. Their widespread use raises concerns about potential hazards to human health, specifically their intestinal pro-inflammatory effects....

Cardiac molecular remodeling by anticancer drugs: Doxorubicin affects more meta...

Doxorubicin (DOX) and mitoxantrone (MTX) are classical chemotherapeutic agents used in cancer that induce similar clinical cardiotoxic effects, although it is not clear if they share similar underlying molecular mechanisms. We aimed to assess the effects of DOX and MTX on the cardiac remodeling, focusing mainly on metabolism and autophagy. Adult male CD-1 mice received pharmacologically relevant cumulative dose...

THE MOLECULAR MECHANISMS INVOLVED IN DOXORUBICIN-INDUCED SKELETAL MUSCLE WASTING

Chemotherapeutic agents like doxorubicin (DOX) are the foundation for the treatment of a variety of malignancies; however, these therapies have several side-effects. DOX may trigger or potentiate the muscle wasting observed in cancer patients, which is particularly worrying in frail old patients. Therefore, it is important to comprehend the mechanisms responsible for DOX-induced toxicity in skeletal muscle, to ...

Molecular alterations underlying Doxorubicin’s Chronic Cardiotoxicity in a mous...

Early pathways of toxicity triggered by 3,4-methylenedioxypyrovalerone unveiled...

Exploring the aging effect of the anticancer drugs doxorubicin and mitoxantrone...

Current cancer therapies are successfully increasing the lifespan of cancer patients. Nevertheless, cardiotoxicity is a serious chemotherapy-induced adverse side effect. Doxorubicin (DOX) and mitoxantrone (MTX) are cardiotoxic anticancer agents, whose toxicological mechanisms are still to be identified. This study focused on DOX and MTX's cardiac mitochondrial damage and their molecular mechanisms. As a hypothe...