2 documents found, page 1 of 1
Polimorfismo em cocristais de benzoilmetronidazol
Costa, Wendell SaraivaBenzoylmetronidazole (BZMD) is an ester derived from metronidazole with antibacterial and antiprotozoal properties, being effective in the treatment of trichomoniasis, balantidiasis, ulcerative gingivitis and some anaerobic bacteria. It belongs to Class IV of the Biopharmaceutical Classification System (BCS), due to its low solubility and permeability. Cocrystals are a feasible alternative particularly for poor...
The design of novel metronidazole benzoate structures: exploring stoichiometric...
Oliveira, Yara Santiago de; Costa, Wendell Saraiva; Borges, Poliana Ferreira; Santana, Maria Silmara Alves de; Ayala, Alejandro PedroThe use of supramolecular synthons as a strategy to control crystalline structure is a crucial factor in developing new solid forms with physicochemical properties optimized by design. However, to achieve this objective, it is necessary to understand the intermolecular interactions in the context of crystal packing. The feasibility of a given synthon depends on its flexibility to combine the drug with a variety...