5 documents found, page 1 of 1
Targeting lactate transport suppresses in vivo breast tumour growth
Morais-Santos, Filipa; Granja, Sara; Miranda-Gonçalves, Vera; Moreira, António H.J.; Queirós, Sandro; Vilaça, João L.; Schmitt, Fernando C.Background: Most cancers, including breast cancer, have high rates of glucose consumption, associated with lactate production, a process referred as “Warburg effect”. Acidification of the tumour microenvironment by lactate extrusion, performed by lactate transporters (MCTs), is associated with higher cell proliferation, migration, invasion, angiogenesis and increased cell survival. Previously, we have described...
Variations of the soft tissue thicknesses external to the ribs in pectus excava...
Rodrigues, Pedro L.; Direito-Santos, Bruno; Moreira, António H.J.; Fonseca, Jaime C.; Pinho, A.C.M.; F. Rodrigues, Nuno; Henriques-Coelho, TiagoBackground: Surgical repair of pectus excavatum (PE) has become more popular due to improvements in the minimally invasive Nuss procedure. The pre-surgical assessment of PE patients requires Computerized Tomography (CT), as the malformation characteristics vary from patient to patient. Objective: This work aims to characterize soft tissue thickness (STT) external to the ribs among PE patients. It also presents ...
Electromagnetic tracker feasibility in the design of a dental superstructure fo...
Moreira, António H.J.; Queirós, Sandro; F. Rodrigues, Nuno; Pinho, A.C. M.; Fonseca, Jaime C.; Vilaça, João L.The success of the osseointegration concept and the Brånemark protocol is highly associated to the accuracy in the production of an implant-supported prosthesis. One of most critical steps for long-term success of these prosthesis is the accuracy obtained during the impression procedure, which is affected by factors such as the impression material, implant position, angulation and depth. This paper investigates...
Artificial neural networks for automatic modelling of the pectus excavatum corr...
Rodrigues, Pedro L.; Moreira, António H.J.; F. Rodrigues, Nuno; Pinho, A. C. M.; Fonseca, Jaime C.; Correia-Pinto, Jorge; Vilaça, João L.Pectus excavatum is the most common deformity of the thorax and usually comprises Computed Tomography (CT) examination for pre-operative diagnosis. Aiming at the elimination of the high amounts of CT radiation exposure, this work presents a new methodology for the replacement of CT by a laser scanner (radiation-free) in the treatment of pectus excavatum using personally modeled prosthesis. The complete eliminat...
Real-time hand tracking for rehabilitation and character animation
Moreira, António H.J.; Queirós, Sandro; Fonseca, José; Rodrigues, Pedro L.; F. Rodrigues, Nuno; Vilaça, João L.Hand and finger tracking has a major importance in healthcare, for rehabilitation of hand function required due to a neurological disorder, and in virtual environment applications, like characters animation for on-line games or movies. Current solutions consist mostly of motion tracking gloves with embedded resistive bend sensors that most often suffer from signal drift, sensor saturation, sensor displacement a...