2 documents found, page 1 of 1
Immunotherapy, immunochemotherapy and chemotherapy for American cutaneous leish...
Mayrink,Wilson; Botelho,Ana Cristina de Carvalho; Magalhães,Paulo Araújo; Batista,Sebastião Mariano; Lima,Antonio de Oliveira; Genaro,OdairThe first choice of treatment for American cutaneous leishmaniasis is the pentavalent antimonial drug. Although it has been shown that this treatment is mostly effective and indicated, some disadvantages should be taken into account such as side effects, long term treatment inconveniences and counter-indication for patients suffering from cardiopathy, nephropathy; yet, aging, pregnancy and other conditions. Wit...
Vaccination of C57BL/10 mice against cutaneous leishmaniasis using killed proma...
Mayrink,Wilson; Santos,Gilmara Cristina dos; Toledo,Vicente de Paulo Coelho Peixoto de; Guimarães,Tânia Mara Pinto DabésAntigenic extracts from five Leishmania stocks were used to vaccinate C57BL/10 mice. The Leishvacin® and PH8 monovalent vaccine yielded the highest IFN-gamma levels in the supernatants of spleen cell culture from vaccinated animals. Each single strain immunized group showed evidence of protective immunity six months after the challenge with promastigotes of Leishmania (Leishmania) amazonensis. No differences we...