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Incidence and prevalence of systemic sclerosis in Campo Grande, State of Mato G...
Horimoto,Alex Magno Coelho; Matos,Erica Naomi Naka; Costa,Márcio Reis da; Takahashi,Fernanda; Rezende,Marcelo Cruz; Kanomata,Letícia BarriosAbstract Introduction: Systemic sclerosis is an autoimmune disease which shows extreme heterogeneity in its clinical presentation and that follows a variable and unpredictable course. Although some discrepancies in the incidence and prevalence rates between geographical regions may reflect methodological differences in the definition and verification of cases, they may also reflect true local differences. Objec...
Recommendations of the Brazilian Society of Rheumatology for diagnosis and trea...
Marques,Claudia Diniz Lopes; Duarte,Angela Luzia Branco Pinto; Ranzolin,Aline; Dantas,Andrea Tavares; Cavalcanti,Nara GualbertoAbstract Chikungunya fever has become a relevant public health problem in countries where epidemics occur. Until 2013, only imported cases occurred in the Americas, but in October of that year, the first cases were reported in Saint Marin island in the Caribbean. The first autochthonous cases were confirmed in Brazil in September 2014; until epidemiological week 37 of 2016, 236,287 probable cases of infection w...
Recommendations of the Brazilian Society of Rheumatology for the diagnosis and ...
Marques,Claudia Diniz Lopes; Duarte,Angela Luzia Branco Pinto; Ranzolin,Aline; Dantas,Andrea Tavares; Cavalcanti,Nara GualbertoAbstract Chikungunya fever has become an important public health problem in countries where epidemics occur because half of the cases progress to chronic, persistent and debilitating arthritis. Literature data on specific therapies at the various phases of arthropathy caused by chikungunya virus (CHIKV) infection are limited, lacking quality randomized trials assessing the efficacies of different therapies. The...
Evaluation of epidural blockade as therapy for patients with sciatica secondary...
Nunes,Rogerio Carlos Sanfelice; Pontes,Elenir Rose Jardim Cury; Costa,Izaias Pereira daABSTRACT OBJECTIVE: Sciatic pain secondary to lumbar disc herniation is a complex condition that is often highly limiting. The causes of pain in disc herniation are multifactorial. Two physiopathological mechanisms are involved in discogenic pain: mechanical deformation of nerve roots and a biochemical inflammatory component resulting from contact between the intervertebral disc and neural tissue, by way of the...
Overlap between systemic sclerosis and rheumatoid arthritis: a distinct clinica...
Horimoto,Alex Magno Coelho; Costa,Izaias Pereira daABSTRACT Introduction: Systemic sclerosis (SSc) is an autoimmune disease of the connective tissue characterized by the triad of vascular injury, autoimmunity (cellular and humoral) and tissue fibrosis. It is estimated that musculoskeletal pain is a common complaint of patients with SSc, ranging from 40 to 80%, and mainly in patients with early diffuse disease. Arthritis, clinically observed, may be a feature se...
Familial autoimmunity and polyautoimmunity in 60 Brazilian Midwest patients wit...
Horimoto,Alex Magno Coelho; Silveira,Aida Freitas do Carmo; Costa,Izaias Pereira daABSTRACT Introduction: Systemic sclerosis (SSc) is a connective tissue disease of unknown etiology, characterized by a triad of vascular injury, autoimmunity and tissue fibrosis. It is known that a positive family history is the greatest risk factor already identified for the development of SSc in a given individual. Preliminary observation of a high prevalence of polyautoimmunity and of familial autoimmunity i...
Autoanticorpos em esclerose sistêmica e sua correlação com as manifestações clí...
Coelho Horimoto,Alex Magno; Costa,Izaias Pereira daIntrodução: a esclerose sistêmica (ES) é uma enfermidade do tecido conjuntivo de caráter autoimune caracterizada pela tríade de injúria vascular, autoimunidade (celular e humoral) e fibrose tecidual. Os autoanticorpos não parecem ser simplesmente epifenômenos, mas sim estarem envolvidos na patogênese da doença. Acredita-se que os autoanticorpos específicos da ES são responsáveis tanto pela amplificação da respo...
Avaliação do desempenho do BASDAI (Bath Ankylosing Spondylitis Disease Activity...
Costa,Izaias Pereira da; Bortoluzzo,Adriana B.; Gonçalves,Célio R.; Silva,José Antonio Braga da; Ximenes,Antonio Carlos; Bértolo,Manoel B.Objetivo Avaliar os resultados da aplicação do Índice de Atividade de Doença da Espondilite Anquilosante de Bath (BASDAI) numa série de pacientes brasileiros com EpA e estabelecer suas correlações com as variáveis específicas do grupo. Métodos Um protocolo comum de investigação foi prospectivamente aplicado em 1.492 pacientes brasileiros classificados como EpA pelos critérios do Grupo Europeu de Estudo das Espo...
Perfil do uso de drogas modificadoras de doença no Registro Brasileiro de Espon...
Kohem,Charles L; Bortoluzzo,Adriana B; Gonçalves,Célio R; Silva,José Antonio Braga da; Ximenes,Antonio Carlos; Bértolo,Manoel B.; Ribeiro,Sandra L.E.Introdução: Poucos estudos avaliaram o perfil do uso de drogas modificadoras de doença (DMD) em pacientes brasileiros com diagnóstico de espondiloartrite (EpA). Métodos: Um protocolo comum de investigação foi prospectivamente aplicado em 1505 pacientes classificados como EpA pelos critérios do Grupo Europeu de Estudo das Espondiloartrites (ESSG), acompanhados em 29 centros de referência em Reumatologia no Brasi...
Glucocorticoid-induced tumor necrosis factor receptor expression in patients wi...
Padovani,Cacilda Tezelli Junqueira; Bonin,Camila Mareti; Tozetti,Ines Aparecida; Ferreira,Alda Maria Teixeira; Fernandes,Carlos Eurico dos SantosIntroduction The progression of human papillomavirus (HPV) infection in the anogenital tract has been associated with the involvement of cells with regulatory properties. Evidence has shown that glucocorticoid-induced tumor necrosis factor receptor (GITR) is an important surface molecule for the characterization of these cells and proposes that GITR ligand may constitute a rational treatment for many cancer typ...