5 documents found, page 1 of 1
Phylogenetic Analysis of Hepatitis C Virus Infections in a Large Belgian Cohort...
Christensen, Kasper T.; Pierard, Florian; Bonsall, David; Bowden, Rory; Barnes, Eleanor; Florence, Eric; Ansari, M. Azim; Nguyen, DungFunding Information: This research and Kasper Thorhauge Christensen was funded by grants from the Fonds Wetenschappelijk Onderzoek Vlaanderen (FWO) (G069214, G0B2317N and 1S38819N). Lize Cuypers acknowledges FWO travel grant for a research visit at the University of Oxford (V431117N). Core funding to the Wellcome Centre for Human Genetics was provided by the Wellcome Trust (award 203141/Z/16/Z). The authors ack...
Full-genome next-generation sequencing of hepatitis C virus to assess the accur...
Christensen, Kasper T.; Pierard, Florian; Beuselinck, Kurt; Bonsall, David; Bowden, Rory; Lagrou, Katrien; Nevens, Frederik; Schrooten, YoeriFunding Information: This work and KTC were supported by grants from the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) ( G069214 , G0B2317N , 1S38819N ). LC acknowledges FWO travel grant for a research visit at University of Oxford ( V431117N ). The authors thank the staff in Oxford in their support of the laboratory work and the donation of the probes used for enrichment of HCV. Publisher Copyright: ©...
Quality control of next-generation sequencing-based HIV-1 drug resistance data ...
Capina, Rupert; Li, Katherine; Kearney, Levon; Vandamme, Anne Mieke; Harrigan, P. Richard; Van Laethem, KristelFunding Information: We acknowledge the Fonds voor Wetenschappelijk Onderzoek Vlaanderen (FWO) (G.0B23.17N) for covering publications costs. Publisher Copyright: © 2020 by the authors.; Next-generation sequencing (NGS) in HIV drug resistance (HIVDR) testing has the potential to improve both clinical and public health settings, however it challenges the normal operations of quality management systems to be more ...
Implications of hepatitis C virus subtype 1a migration patterns for virus genet...
Cuypers, Lize; Vrancken, Bram; Fabeni, Lavinia; Marascio, Nadia; Cento, Valeria; Di Maio, Velia Chiara; Aragri, Marianna; Pineda-Peña, Andrea ClemenciaBackground: In-depth phylogeographic analysis can reveal migration patterns relevant for public health planning. Here, as a model, we focused on the provenance, in the current Italian HCV subtype 1a epidemic, of the NS3 resistance-associated variant (RAV) Q80K, known to interfere with the action of NS3/4A protease inhibitor simeprevir. HCV1a migration patterns were analysed using Bayesian phylodynamic tools, ca...
Performance of an in-house human immunodeficiency virus type 1 genotyping syste...
Alemán, Yoan; Vinken, Lore; Kourí, Vivian; Pérez, Lissette; Álvarez, Alina; Abrahantes, Yeissel; Fonseca, Carlos; Pérez, Jorge; Correa, ConsueloPMID: 25671421 WOS:000349545300039; As commercial human immunodeficiency virus type 1 drug resistance assays are expensive, they are not commonly used in resource-limited settings. Hence, a more affordable in-house procedure was set up taking into account the specific epidemiological and economic circumstances of Cuba. The performance characteristics of the in-house assay were evaluated using clinical samples w...