2 documents found, page 1 of 1
Neuroprotective effects of mitochondria-targeted antioxidants in a Parkinson’s ...
Costa , I.; Benfeito , S.; Silva , V.; Cagide , F.; Borges , F.; Remião , F.; Silva , R.Background: Parkinson’s disease (PD) is a neurodegenerative disease with early prominent death of dopaminergic neurons in the substantia nigra pars compacta, concurrently with Lewys body formation, iron accumulation, oxidative stress and ferroptosis[1–3]. Since there is no effective therapy capable of stopping/delaying disease progression, phenolic acids such as hydroxycinnamic and hydroxybenzoic acids (HCA and...
3-Hydroxypyridin-4-one based derivatives as promising neuroprotective agents fo...
Silva , V.; Benfeito, S.; Lima , C.; Chavarria, D.; Gonçalves, T.; Costa , I.; Remião , F.; Borges, F.; Silva , R.Background: Parkinson’s Disease (PD) is a multifactorial, complex and progressive neurodegenerative disease, characterized by the degeneration of dopaminergic neurons in the substantia nigra pars compacta [1,2]. Several pathophysiological mechanisms are involved in PD, namely Lewy bodies formation, mitochondrial dysfunction, neuroinflammation, oxidative stress and iron accumulation within the brain [3]. Iron tr...