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Identification of a bioactive compound isolated from Brazilian propolis type 6.
Castro, Myrella Lessio; Nascimento, Andréa Mendes do; Ikegaki, Masaharu; Costa Neto, Cláudio Miguel da; Alencar, Severino Matias de; Rosalen, Pedro LuizA prenylated benzophenone, hyperibone A, was isolated from the hexane fraction of Brazilianpropolistype6. Its structure was determined by spectral analysis including 2D NMR. This compound exhibited cytotoxic activity against HeLa tumor cells (IC50 = 0.1756 μM), strong antimicrobial activity (MIC range—0.73–6.6 μg/mL; MBC range—2.92–106 μg/mL) against Streptococcus mutans, Streptococcus sobrinus, Streptococcus o...
Data: 2012
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Origem: Oasisbr