5 documents found, page 1 of 1
Mesenchymal stem cells empowering tendon regenerative therapies
Costa-Almeida, Raquel; Calejo, Isabel; Gomes, Manuela E.Tendon tissues have limited healing capacity. The incidence of tendon injuries and the unsatisfactory functional outcomes of tendon repair are driving the search for alternative therapeutic approaches envisioning tendon regeneration. Cellular therapies aim at delivering adequate, regeneration-competent cell types to the injured tendon and toward ultimately promoting its reconstruction and recovery of functional...
A platelet lysate antibacterial bioactive patch for tendon repair
Costa-Almeida, Raquel; Franco, Albina Ribeiro; Leonor, I. B.; Babo, Pedro Miguel Sousa; Pesqueira, Tamagno; Reis, R. L.; Gomes, Manuela E.Platelet lysate (PL) is a class of platelet-rich hemoderivatives produced by cryogenic disruption of platelet concentrates, originating a pool of supra-physiological concentrations of growth factors (GFs) that is being widely explored in the medical field, namely in sports medicine and orthopaedics. In this concern, patch augmentation strategies have been receiving increased attention as the basis for the devel...
Simulated hypergravity induces changes in human tendon-derived cells: from cell...
Costa-Almeida, Raquel; Carvalho, Daniel T. O.; Ferreira, Miguel J. S.; Pesqueira, Tamagno; Monici, Monica; van Loon, Jack J. W. A.; Granja, Pedro L.Gravity influences physical and biological processes, having an impact on development, as well as homeostasis of living systems. The musculoskeletal system is comprised of several mechano- responsive tissues and altered gravitational forces are known to influence distinct properties, including bone mineral density and skeletal muscle mass. This is particularly relevant in a near- weightlessness (microgravity) e...
Monocarboxylate transporter 1 is a key player in glioma-endothelial cell crosstalk
Miranda-Gonçalves, Vera; Bezerra, Filipa; Costa-Almeida, Raquel; Freitas-Cunha, Marta; Soares, Raquel; Martinho, Olga; Reis, R. M.; Pinheiro, CélineGlioblastoma (GBM) is one of the most glycolytic and angiogenic human tumors, characteristics that contribute to the poor prognosis associated with this type of tumor. A lactate shuttle has been described between tumor cells and endothelial cells (ECs), with the monocarboxylate transporters (MCTs) acting as important players in this tumor-EC communication. In this study, we aimed to understand how the tumor mic...
Antibacterial potential of platelet lysate membranes for orthopedic applications
Costa-Almeida, Raquel; Franco, Albina Ribeiro; Leonor, I. B.; Babo, Pedro Miguel Sousa; Reis, R. L.; Gomes, Manuela E.[Excerpt] Statement of Purpose: Microbial infections are one of the most serious complications on post-transplant and surgery. The recurrent use of antibiotic therapeutic to treat such infections has led to the increase of microbial strain resistance, and thus, reducing antibiotic efficacy1. Platelet-rich hemoderivatives (PRHd) gained great interest in the medical field, namely in sports medicine and orthopaedi...