10 documents found, page 1 of 1

Fostering conservancy through bioprospection: the pharmaceutical value of the b...

The inherent value of nature is immeasurable. That being said, through bioprospection – the systematic search for functional products or processes from living organisms –, the oceans and marine life have emerged as a relevant source of biodiscoveries that hold significant economic worth. Particularly considering the pharmaceutical industry, an increasing number of natural molecules of marine origin have been ma...

Dredging impacts on the toxicity and development of sediment quality values in ...

Made available in DSpace on 2021-06-25T10:47:05Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-02-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação Cearense de Apoio ao Desenvolvimento Científico e Tecnológico; Sediment dredging impacts coastal environments by promoting the resuspension of fine particles and remobilization of contaminants that may trigger toxic effects. ...

Use of bioaffiity chromatography in the prospection of anticancer substances in...

Biomarkers responses of the clam Anomalocardia flexuosa in sediment toxicity bi...

Made available in DSpace on 2020-12-12T01:24:29Z (GMT). No. of bitstreams: 0 Previous issue date: 2020-05-01; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação para a Ciência e a Tecnologia; Few test organisms are employed for sediment toxicity assessments in Tropical regions, including Brazil. We assessed the ability of the clam Anomalocardia flexuosa to respond to contamination in...

Involvement of intrinsic mitochondrial pathway in neosergeolide-induced apoptos...

Context: Quassinoids are biologically active secondary metabolites found exclusively in the Simaroubaceae family of plants. These compounds generally present important biological properties, including cytotoxic and antitumor properties. Objective: In the present study, the cytotoxic effects of neosergeolide, a quassinoid isolated from Picrolemma sprucei Hook. f., were evaluated in human promyelocytic leukemia c...

Biological activity of neosergeolide and isobrucein B (and two semi-synthetic d...

In the present study, in vitro techniques were used to investigate a range of biological activities of known natural quassinoids isobrucein B (1) and neosergeolide (2), known semi-synthetic derivative 1,12-diacetylisobrucein B (3), and a new semi-synthetic derivative, 12-acetylneosergeolide (4). These compounds were evaluated for general toxicity toward the brine shrimp species Artemia franciscana, cytotoxicity...

Marine drugs for cancer: surfacing biotechnological innovations from the oceans

This review will discuss the contributions of marine natural molecules, a source only recently found to have pharmaceutical prospects, to the development of anticancer drugs. Of the seven clinically utilized compounds with a marine origin, four are used for the treatment of cancer. The development of these drugs has afforded valuable knowledge and crucial insights to meet the most common challenges in this ende...

Hydrocarbons in surface sediments of harbor areas in a tropical region (Ceará s...

Made available in DSpace on 2018-12-11T16:41:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-04-01; Sediment samples collected in two harbors of a tropical region of Brazil were investigated for the distribution of linear alkylbenzenes (LABs), aliphatic (AHs) and polycyclic aromatic hydrocarbons (PAHs). The levels of hydrocarbons in sediments from Mucuripe and Pecém harbors were lower than those repor...

Fluorescent kapakahines serve as non-toxic probes for live cell Golgi imaging

Synthesis and biological evaluation of new salicylate macrolactones from anacar...

No âmbito de uma linha de pesquisa que visa a obtenção de novas substâncias bioativas, a partir de lipídeos fenólicos não-isoprenóides de Anacardium occidentale, descrevemos a síntese e avaliação citotóxica de novas macrolactonas salicílicas, preparadas a partir da mistura de ácidos anacárdicos, principal constituinte do líquido da casca da castanha de caju (LCC) in natura.; In connection with our ongoing inves...