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Pyrimidine alkaloids from Eudistoma vannamei
Takeara,Renata; Basso,Thiago Olitta; Jimenez,Paula Christine; Costa-Lotufo,Letícia Veras; Lopes,Norberto Peporine; Lopes,João Luis CallegariAbstract Methanolic extracts of the Brazilian endemic ascidian Eudistoma vannamei have been extensively studied for their cytotoxic activity against several human cancer cell lines. Previous work reported the occurrence of purine derivatives and staurosporine alkaloids as the major nitrogen-containing compounds. In this study, we report the occurrence of three pyrimidine alkaloids in addition to cholesterol, si...
Trachylobane and kaurane diterpenes from Croton floribundus spreng
Uchôa,Paula Karina S.; Silva Jr.,José Nunes da; Silveira,Edilberto Rocha; Lima,Mary Anne S.; Braz-Filho,Raimundo; Costa-Lotufo,Letícia VerasA new trachylobane diterpene ent-trachyloban-18,19-diol (1) was isolated from root bark of Croton floribundus, along with known diterpenes ent-trachyloban-19-oic acid (2), 15b-hydroxy-ent-trachyloban-19-oic acid (3), ent-trachyloban-19-ol (4), ent-kaur-16-en-19-oic acid (5), ent-kaur-16-ene-6a,19-diol (6) and ent-16a-hydroxykaur-11-en-19-oic acid (7). ent-trachyloban-18,19-diol (1) was submitted to derivatizati...
Cytotoxic lipidic α-amino acids from the zoanthid Protopalythoa variabilis from...
Wilke,Diego Veras; Jimenez,Paula Christine; Pessoa,Claudia; Moraes,Manoel Odorico de; Araújo,Renata Mendonça; Silva,Wildson Max Barbosa daTwo lipidic α-amino acids 1a and 1b were isolated from the zoanthid Protopalythoa variabilis using a bioguided fractionation for cytotoxic activity. The structures of the metabolites were determined by spectroscopic methods, including NMR (nuclear magnetic resonance) ¹H e 13C, IR (infrared) and high resolution mass spectrometry (positive mode). The cytotoxic activity of the crude extract, as well as of the mixt...
Composição química e atividade biológica de extrato oleoso de própolis: uma alt...
Buriol,Lilian; Finger,Daiane; Schmidt,Eduardo Morgado; Santos,Julio M. T. dos; Rosa,Marcos Roberto da; Quináia,Sueli Pércio; Torres,Yohandra ReyesPropolis is mostly used as hydroalcoholic extract. Recently there has been a growing number of patents dealing with new solvents for preparing propolis extracts. This study aimed to prepare edible oil propolis extracts and compare their chemical composition and biological activity with ethanolic propolis extracts. ESI-MS and spectrophotometric methods were used for qualitative and quantitative analyses, respect...
Organismos marinhos como fonte de novos fármacos: histórico & perspectivas
Costa-Lotufo,Letícia Veras; Wilke,Diego Veras; Jimenez,Paula Christine; Epifanio,Rosângela de A.Though sharing only a short part on the natural products timeline, the studies on marine products has already handed in four new drugs to the clinical arsenal and brought up a long and promising list of unique molecules to pre-clinical and clinical trials. Thus, as the available analytical resources improve and the interest of large pharmaceutical companies arises, medical use of marine products has definitely ...
Constituintes químicos da ascídia didemnum psammatodes (sluiter, 1895) coletada...
Takeara,Renata; Lopes,João Luis Callegari; Lopes,Norberto Peporine; Jimenez,Paula Christine; Costa-Lotufo,Letícia Veras; Lotufo,Tito Monteiro da CruzChemical investigation of the methanolic extract of the ascidian Didemnum psammatodes has led to the identification of the nucleosides 2'-deoxyuridine (1), thymidine (2), 2'-deoxyinosine (3) and 2'-deoxyguanosine (4), the steroids cholestanol, cholestanone and stigmasterol in mixture and batyl alcohol plus two analogs, 1-heptadecyloxy-2,3-propanediol and 1-nonadecyloxy-2,3-propanediol in mixture. Their structur...
Modelo experimental de tumor na cavidade oral de ratos com carcinossarcoma de W...
Alves,Ana Paula Negreiros Nunes; Guedes,Rafael Cardoso; Costa-Lotufo,Letícia Veras; Moraes,Maria Elisabete Amaral de; Pessoa,Cláudia do ÓOBJETIVO: Estabelecer um modelo experimental de desenvolvimento tumoral na cavidade oral de ratos, permitindo, assim, o estudo da osteólise induzida pelo tumor nos ossos do complexo maxilomandibular como também nas estruturas dentais, através da caracterização histomorfológica da reabsorção óssea e dentária. MÉTODOS: Uma suspensão de células tumorais (0,1mL) do Carcinossarcoma de Walker 256, na concentração de ...