8 documents found, page 1 of 1
Isolation, Absolute Configuration and Cytotoxic Activities of Alkaloids from Hi...
Lianza,Mariacaterina; Verdan,Maria Helena; Andrade,Jean Paulo de; Poli,Ferruccio; Almeida,Larissa C. de; Costa-Lotufo,Leticia V.; Cunha Neto,ÁlvaroThe phytochemical study of Hippeastrum goianum led to the identification of 13 compounds by means of gas chromatography-mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). Compounds 7-demethoxy-9-O-methylhostasine (1) and 7-deoxi-trans-dihydronarciclasine (2) had their absolute configurations determined by vibrational circular dichroism (VCD). This is the first time that compound 1 is described in t...
Bioprospecting Anticancer Compounds from the Marine-Derived Actinobacteria Acti...
Silva,Amaro E. T.; Guimarães,Larissa A.; Ferreira,Elthon G.; Torres,Maria da Conceição M.; Silva,Alison B. da; Branco,Paola C.The actinomycete strain BRA 177 was recovered from sediment samples collected at the St. Peter and St. Paul Archipelago, Brazil. This work accessed the ability of this strain, identified as Actinomadura sp., to produce bioactive metabolites by exploring the genome and characterizing chemistry and cytotoxicity of isolated compounds. From the crude ethyl acetate extract, the pigments nonylprodigiosin, cyclononylp...
Miscellaneous Diterpenes from the Aerial Parts of Plectranthus ornatus Codd
Ávila,Fábio N.; Pinto,Francisco C. L.; Sousa,Thiciana S.; Torres,Maria Conceição M.; Costa-Lotufo,Leticia V.; Rocha,Danilo D.; Vasconcelos,Mayron A. deFive new diterpenes derivatives named as ornatin A, B, C, D and E, in addition to six known related diterpenes were isolated from the aerial parts of cultivated specimens of Plectranthus ornatus. The structures were elucidated using a combination of 1D/2D nuclear magnetic resonance (NMR) spectroscopy, high-resolution electrospray ionization mass spectrometry (HRESIMS) and comparison with published NMR data of a...
Elucidating the Mode of Action of Marine Natural Products through an Immunoaffi...
La Clair,James J.; Fenical,William; Costa-Lotufo,Leticia V.Understanding the target and mode of action (MOA) of small molecules activity has become a critical feature in guiding the transition between drug discovery and clinical evaluation. While classically placed at the latter stages of a discovery program, we now describe how addressing the mode of action of natural products at the early stages of a program provides an important vehicle to inform the drug discovery ...
Amphidinolide P from the Brazilian octocoral Stragulum bicolor
Sousa,Thiciana S.; Nuzzo,Genoveffa; Torres,Maria C.M.; Lopes,Norberto P.; Cutignano,Adele; Jimenez,Paula C.; Santos,Evelyne A.; Gomes,Bruno A.Abstract Dinoflagellates are an important source of unique bioactive secondary metabolites. Symbiotic species, commonly named zooxanthellae, transfer most of their photosynthetically fixed carbon to their host. The mutualistic relationship provides the organic metabolites used for energy production but there are very few reports of the role of the dinoflagellates in the production of secondary metabolites in th...
Bioprospecting for bioactives from seaweeds: potential, obstacles and alternatives
Pereira,Renato C.; Costa-Lotufo,Leticia V.Seaweeds are potential sources of high biotechnological interest due to production of a great diversity of compounds exhibiting a broad spectrum of biological activities. On the other hand, there is an urgent need for management options for a sustainable approach to the use of marine organisms as a source of bioactive compounds. This review discusses the bioprospection for bioactive seaweed compounds as pharmac...
Systematic UPLC-ESI-MS/MS study on the occurrence of staurosporine and derivati...
Andréo,Márcio A.; Jimenez,Paula C.; Siebra,Josy B. C. N.; Costa-Lotufo,Leticia V.; Vessecchi,Ricardo; Niehues,Michael; Lopes,João L. C.Former bioactivity-guided analysis of the marine invertebrate Eudistoma vannamei led to the isolation of staurosporine derivatives, which revealed strong cytotoxic activity against several human cancer cell lines. The occurrence of such alkaloids in E. vannamei may be correlated to the presence of associated biota, such as Streptomyces bacteria. In agreement to this hypothesis, marine microorganisms associated ...
Folk uses and pharmacological properties of Casearia sylvestris: a medicinal re...
Ferreira,Paulo Michel P.; Costa-Lotufo,Leticia V.; Moraes,Manoel O.; Barros,Francisco W.A.; Martins,Aline M.A.; Cavalheiro,Alberto J.Folk uses and scientific investigations have highlighted the importance of Casearia sylvestris extracts and their relevant bioactive potential. The aim of this work was to review the pharmacological properties of C. sylvestris, emphasizing its anti-ulcer, anti-inflammatory, anti-ophidian and antitumor potentialities. Ethanolic extracts and essential oil of their leaves have antiulcerogenic activity and reduce g...