4 documents found, page 1 of 1
Regulation of angiotensin II receptors levels during rat induced pulpitis
Souza, Pedro P.C.; Fukada, Sandra Y.; Cunha, Fernando Q.; Costa, Carlos A.S.; Costa-Neto, Claudio M.Made available in DSpace on 2022-04-29T08:43:18Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-04-05; A change in the microcirculatory hemodynamic is one of the most important events in inflammation. In the dental pulp, which is a connective tissue surrounded by a mineralized dentine substrate, disturbance in the blood flow as well as plasma extravasation may increase the pulp pressure and cause local i...
Activation of Toll-like receptor 2 induces B 1 and B 2 kinin receptors in human...
Souza, Pedro P. C. [UNESP]; Lundberg, Pernilla; Lundgren, Inger; Magalhães, Fernando A. C. [UNESP]; Costa-Neto, Claudio M.; Lerner, Ulf H.Made available in DSpace on 2019-10-06T16:49:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-12-01; The regulation of the kallikrein-kinin system is an important mechanism controlling vasodilation and promoting inflammation. We aimed to investigate the role of Toll-like receptor 2 (TLR2) in regulating kinin B 1 and B 2 receptor expression in human gingival fibroblasts and in mouse gingiva. Both P. gin...
Recent updates on GPCR biased agonism
Pupo, Andre S. [UNESP]; Duarte, Diego A.; Lima, Vanessa [UNESP]; Teixeira, Larissa B.; Parreiras-e-Silva, Lucas T.; Costa-Neto, Claudio M.Made available in DSpace on 2018-11-26T17:06:44Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-10-01; G protein-coupled receptors (GPCRs) are the most important targets for drug discovery and not surprisingly similar to 40% of all drugs currently in the market act on these receptors. Currently, one of the most active areas in GPCRs signaling is biased agonism, a phenomenon that occurs when a given ligan...
Citocalasinas produzidas por Xylaria sp., um fungo endofítico de Piper aduncum ...
Silva, Geraldo H. [UNESP]; Oliveira, Camila M. de [UNESP]; Teles, Helder L. [UNESP]; Bolzani, Vanderlan da Silva [UNESP]; Araújo, Angela Regina [UNESP]Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:48:51Z No. of bitstreams: 1 S0100-40422010001000006.pdf: 198980 bytes, checksum: ccb17061fce944dc07fdce80ef8dd58c (MD5); Made available in DSpace on 2013-08-22T18:48:51Z (GMT). No. of bitstreams: 1 S0100-40422010001000006.pdf: 198980 bytes, checksum: ccb17061fce944dc07fdce80ef8dd58c (MD5) Previous issue date: 2010-01-01; Made availabl...