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It comes from the sea: macroalgae-derived bioactive compounds with anti-cancer ...

Nova, Paulo; Gomes, Ana Maria; Costa-Pinto, Ana R.

Nature derived compounds represent a valuable source of bioactive molecules with enormous potential. The sea is one of the richest environments, full of skilled organisms, where algae stand out due to their unique characteristics. Marine macroalgae adapt their phenotypic characteristics, such as chemical composition, depending on the environmental conditions where they live. The compounds produced by these orga...


Chemical and antioxidant properties of solvent and enzyme-assisted extracts of ...

Nova, Paulo; Cunha, Sara A.; Costa-Pinto, Ana R.; Gomes, Ana Maria

Extraction strategies impact the efficiency and nature of extracted compounds. This work assessed the chemical composition and antioxidant capacity of ethanolic, hydroethanolic, and aqueous versus enzyme-assisted extracts (isolated or with the sequential use of alcalase®, cellulase®, and viscozyme®) of the macroalgae Fucus vesiculosus (brown, Phaeophyceae) and Porphyra dioica (red, Rhodophyta. For both macroalg...


Sargassum muticum and Osmundea pinnatifida Enzymatic Extracts: Chemical, Struct...

Rodrigues, Dina; Costa-Pinto, Ana R.; Sousa, Sérgio; Vasconcelos, Marta W.; Pintado, Manuela M.; Pereira, Leonel; Rocha-Santos, Teresa A. P.

Seaweeds, which have been widely used for human consumption, are considered a potential source of biological compounds, where enzyme-assisted extraction can be an efficient method to obtain multifunctional extracts. Chemical characterization of Sargassum muticum and Osmundea pinnatifida extracts obtained by Alcalase and Viscozyme assisted extraction, respectively, showed an increment of macro/micro elements in ...


Influence of PDLA nanoparticles size on drug release and interaction with cells

Cartaxo, Ana Luísa; Costa-Pinto, Ana R.; Martins, Albino; Faria, Susana; Gonçalves, Virgínia M. F.; Tiritan, Maria Elizabeth

Polymeric nanoparticles (NPs) are strong candidates for the development of systemic and targeted drug delivery applications. Their size is a determinant property since it defines the NP-cell interactions, drug loading capacity, and release kinetics. Herein, poly(d,l-lactic acid) (PDLA) NPs were produced by the nanoprecipitation method, in which the influence of type and concentration of surfactant as well as PD...


Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membran...

Serôdio, Ricardo; Schickert, Sónia L.; Costa-Pinto, Ana R.; Dias, Juliana R.; Granja, Pedro L.; Yang, Fang; Oliveira, Ana L.

In this study, silk fibroin (SF)/poly(ethylene oxide) (PEO) membranes were designed and fabricated by combining ultrasound sonication prior to electrospinning (0 to 20 min) as a strategy to physically control the rheological properties of solutions (10 to 30% w/v PEO) and to improve the spinnability of the system. PEO has proved to be essential as a co-spinning agent to assure good membrane reproducibility and ...

Date: 2019   |   Origin: IC-online

Sargassum muticum and Osmundea pinnatifida enzymatic extracts: chemical, struct...

Rodrigues, Dina; Costa-Pinto, Ana R.; Sousa, Sérgio; Vasconcelos, Marta W.; Pintado, Manuela M.; Pereira, Leonel; Rocha-Santos, Teresa A. P.

Seaweeds, which have been widely used for human consumption, are considered a potential source of biological compounds, where enzyme-assisted extraction can be an efficient method to obtain multifunctional extracts. Chemical characterization of Sargassum muticum and Osmundea pinnatifida extracts obtained by Alcalase and Viscozyme assisted extraction, respectively, showed an increment of macro/micro elements in ...


Ultrasound sonication prior to electrospinning tailors silk fibroin/PEO membran...

Serôdio, Ricardo; Schickert, Sónia L.; Costa-Pinto, Ana R.; Dias, Juliana R.; Granja, Pedro L.; Yang, Fang; Oliveira, Ana L.

In this study, silk fibroin (SF)/poly(ethylene oxide) (PEO) membranes were designed and fabricated by combining ultrasound sonication prior to electrospinning (0 to 20 min) as a strategy to physically control the rheological properties of solutions (10 to 30% w/v PEO) and to improve the spinnability of the system. PEO has proved to be essential as a co-spinning agent to assure good membrane reproducibility and ...


Thermal annealed silk fibroin membranes for periodontal guided tissue regeneration

Geão, Catarina; Costa-Pinto, Ana R.; Cunha-Reis, Cassilda; Ribeiro, Viviana P.; Vieira, Sílvia; Oliveira, Joaquim M.; Reis, Rui L.; Oliveira, A. L.

Guided tissue regeneration (GTR) is a surgical procedure applied in the reconstruction of periodontal defects, where an occlusive membrane is used to prevent the fast-growing connective tissue from migrating into the defect. In this work, silk fibroin (SF) membranes were developed for periodontal guided tissue regeneration. Solutions of SF with glycerol (GLY) or polyvinyl alcohol (PVA) where prepared at several...


Influence of PDLA nanoparticles size on drug release and interaction with cells

Cartaxo, Ana Luísa; Costa-Pinto, Ana R.; Martins, Albino; Faria, Susana; Gonçalves, Virgínia M. F.; Tiritan, Maria Elizabeth; Ferreira, Helena

Polymeric nanoparticles (NPs) are strong candidates for the development of systemic and targeted drug delivery applications. Their size is a determinant property since it defines the NP–cell interactions, drug loading capacity, and release kinetics. Herein, poly(D,L-lactic acid) (PDLA) NPs were produced by the nanoprecipitationmethod, in which the influence of type and concentration of surfactant as well as PDL...


Chitosan and codfish hydroxyapatite formulation to be used as coating material ...

Costa-Pinto, Ana R.; Lemos, Ana L.; Piccirillo, Clara; Tavaria, Freni K; Pintado, Manuela E.


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