10 documents found, page 1 of 1
Alendronic Acid as Ionic Liquid: New Perspective on Osteosarcoma
Teixeira, Sónia; Santos, Miguel M.; Fernandes, Maria H.; Costa-Rodrigues, Joao; Branco, Luís C.Herein the quantitative synthesis of eight new mono- and dianionic Organic Salts and Ionic Liquids (OSILs) from alendronic acid (ALN) is reported by following two distinct sustainable and straightforward methodologies, according to the type of cation. The prepared ALN-OSILs were characterized by spectroscopic techniques and their solubility in water and biological fluids was determined. An evaluation of the tox...
Differential effects of antiepileptic drugs on human bone cells
Rocha, Sara; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria Helena; Costa-Rodrigues, JoaoAntiepileptic drugs (AED) have been associated to in vivo deleterious consequences in bone tissue. The present work aimed to characterize the cellular and molecular effects of five different AED on human osteoclastogenesis and osteblastogenesis. It was observed that the different drugs had the ability to differentially modulate both processes, in a way dependent on the identity and dose of the AED. Shortly, val...
A Novel Approach for Bisphosphonates: Ionic Liquids and Organic Salts from Zole...
Teixeira, Sónia; Santos, Miguel M.; Ferraz, Ricardo; Prudêncio, Cristina; Fernandes, Maria H.; Costa-Rodrigues, Joao; Branco, Luís C.Novel ionic liquids and organic salts based on mono- or dianionic zoledronate and protonated superbases, choline and n-alkylmethylimidazolium cations, were prepared and characterized by spectroscopic and thermal analyses. Most of the prepared salts display amorphous structures and very high solubility in water and saline solutions, especially the dianionic salts. Among the zoledronate-based ionic compounds, tho...
Vegetarianism during pregnancy: Risks and benefits
Costa-Rodrigues, Joao; Sá-Azevedo, Rute; Balinha, João; Ferro, GraçaBackground During pregnancy, women face continuous nutritional challenges. Although it is a personal choice, the adoption of a vegetarian dietary pattern during pregnancy must be regarded as a situation that may be associated with some risks and benefits for the mother and the fetus. Scope and Approach In the present review, the most frequent nutritional deficits among pregnant vegetarians will be discussed, na...
Osteoclastogenic differentiation of human precursor cells over micro- and nanos...
Costa-Rodrigues, Joao; Carmo, S.; Perpétuo, I. P.; Monteiro, F. J.; Fernandes, M. H.Background: Surface topography is a key parameter in bone cells–biomaterials interactions. This study analyzed the behavior of human osteoclast precursor cells cultured over three hydroxyapatite (HA) surfaces ranging from a micro- to nanoscale topography. Methods: HA surfaces were prepared with microsized HA particles, at 1300 °C (HA1), andwith nanosized HA particles at 1000 °C (HA2) and 830 °C (HA3). Human ost...
Testing the variability of PSA expression by different human prostate cancer ce...
Rebelo, Tânia S.C.R.; Noronha, João P.; Galésio, Marco; Santos, Hugo; Diniz, Mário; Sales, M. Goreti F.; Fernandes, Maria H.; Costa-Rodrigues, JoaoProstate Specific Antigen (PSA) is widely used as a biomarker for prostate cancer. Recently, an electrochemical biosensor for PSA detection by means ofmolecularly imprinted polymers (MIPs)was developed. Thiswork evaluated the performance and the effectiveness of that PSA biosensor in screening the biomarker PSA in biological mediawith complex composition, collected fromdifferent human prostate cell line culture...
Antitumor Activity of Ionic Liquids Based on Ampicillin
Ferraz, Ricardo; Costa-Rodrigues, Joao; Fernandes, Maria H.; Santos, Miguel M.; Marrucho, Isabel M.; Rebelo, Luís Paulo N.; Prudêncio, CristinaSignificant antiproliferative effects against various tumor cell lines were observed with novel ampicillin salts as ionic liquids. The combination of anionic ampicillin with appropriate ammonium, imidazolium, phosphonium, and pyridinium cations yielded active pharmaceutical ingredient ionic liquids (API-ILs) that show potent antiproliferative activities against five different human cancer cell lines: T47D (brea...
Exploring bioactive properties of marine cyanobacteria Isolated from the Portug...
Costa, Margarida; Garcia, Mónica; Costa-Rodrigues, Joao; Costa, Maria Sofia; Ribeiro, Maria João; Fernandes, Maria Helena; Barros, PiedadeThe oceans remain a major source of natural compounds with potential in pharmacology. In particular, during the last few decades, marine cyanobacteria have been in focus as producers of interesting bioactive compounds, especially for the treatment of cancer. In this study, the anticancer potential of extracts from twenty eight marine cyanobacteria strains, belonging to the underexplored picoplanktonic genera, C...
Complex Effect of Hydroxyapatite Nanoparticles on the Differentiation and Funct...
Costa-Rodrigues, Joao; Silva, Ana; Santos, Catarina; Almeida, Maria Margarida; Costa, Maria Elisabete; Fernandes, Maria HelenaNanosized hydroxyapatite (HA) is a promising material in clinical applications targeting the bone tissue. NanoHA is able to modulate bone cellular events, which accounts for its potential utility, but also raises safety concerns regarding the maintenance of the bone homeostasis. This work analyses the effects of HA nanoparticles (HAnp) on osteoclastic differentiation and activity, an issue that has been barely ...
Marine cyanobacteria compounds with anticancer properties: a review on the impl...
Costa, Margarida; Costa-Rodrigues, Joao; Fernandes, Maria Helena; Barros, Piedade; Vasconcelos, Vítor; Martins, RosarioMarine cyanobacteria have been considered a rich source of secondary metabolites with potential biotechnological applications, namely in the pharmacological field. Chemically diverse compounds were found to induce cytoxicity, anti-inflammatory and antibacterial activities. The potential of marine cyanobacteria as anticancer agents has however been the most explored and, besides cytotoxicity in tumor cell lines,...