2 documents found, page 1 of 1
Is the proteome of bronchoalveolar lavage extracellular vesicles a marker of ad...
Carvalho, AS; Moraes, MCS; Na, CH; Fierro-Monti, I; Henriques, A; Zahedi, S; Bodo, C; Tranfield, EM; Sousa, AL; Farinho, A; Rodrigues, LV; Pinto, PAcellular bronchoalveolar lavage (BAL) proteomics can partially separate lung cancer from non-lung cancer patients based on principal component analysis and multivariate analysis. Furthermore, the variance in the proteomics data sets is correlated mainly with lung cancer status and, to a lesser extent, smoking status and gender. Despite these advances BAL small and large extracellular vehicles (EVs) proteomes r...
Transcriptome Reprogramming of CD11b(+) Bone Marrow Cells by Pancreatic Cancer ...
Maia, J; Otake, AH; Poças, J; Carvalho, AS; Beck, HC; Magalhães, A; Matthiesen, R; Strano Moraes, MC; Costa-Silva, BPancreatic cancers (PC) are highly metastatic with poor prognosis, mainly due to delayed detection. We previously showed that PC-derived extracellular vesicles (EVs) act on macrophages residing in the liver, eliciting extracellular matrix remodeling in this organ and marked hepatic accumulation of CD11b+ bone marrow (BM) cells, which support PC liver metastasis. We here show that PC-EVs also bind to CD11b+ BM c...