5 documents found, page 1 of 1
Macrophage inflammatory and metabolic responses to graphene-based nanomaterials...
Cicuéndez, Mónica; Fernandes, Márcia; Ayán-Varela, Miguel; Oliveira, Helena; Feito, María José; Diez-Orejas, Rosalía; Paredes, Juan I.The preparation of graphene-based nanomaterials (GBNs) with appropriate stability and biocompatibility is crucial for their use in biomedical applications. In this work, three GBNs differing in size and/or functionalization have been synthetized and characterized, and their in vitro biological effects were compared. Pegylated graphene oxide (GO-PEG, 200-500 nm) and flavin mononucleotide-stabilized pristine grap...
Metabolomic response of osteosarcoma cells to nanographene oxide-mediated hyper...
Cicuéndez, Monica; Flores, Joana; Oliveira, Helena; Portolés, M. Teresa; Vallet-Regí, María; Vila, Mercedes; Duarte, Iola F.Nanographene oxide (nGO)-mediated hyperthermia has been increasingly investigated as a localized, minimally invasive anticancer therapeutic approach. Near InfraRed (NIR) light irradiation for inducing hyperthermia is particularly attractive, because biological systems mostly lack chromophores that absorb in this spectral window, facilitating the selective heating and destruction of cells which have internalized...
Three-dimensional printed PCL-hydroxyapatite scaffolds filled with CNTs for bon...
Goncalves, Elsa M.; Oliveira, Filipe J.; Silva, Rui F.; Neto, Miguel A.; Helena Fernandes, M.; Amaral, Margarida; Vallet-Regi, Maria; Vila, MercedesA three-phase [nanocrystalline hydroxyapatite (HA), carbon nanotubes (CNT), mixed in a polymeric matrix of polycaprolactone (PCL)] composite scaffold produced by 3D printing is presented. The CNT content varied between 0 and 10 wt % in a 50 wt % PCL matrix, with HA being the balance. With the combination of three well-known materials, these scaffolds aimed at bringing together the properties of all into a uniqu...
Nanographene Oxide Functionalization with Organic and Hybrid Organic-Inorganic ...
Jaggernauth, Aneeta; Silva, Ricardo M.; Neto, Miguel A.; Hortiguela, Maria J.; Goncalves, Gil; Singh, Manoj K.; Oliveira, Filipe J.; Silva, Rui F.The functionalization of nanographene oxide (GO) with polymers is desirable for increasing the interface compatibility of GO, thereby enabling its use in a variety of applications such as biomedical and energy storage systems. Typically, wet chemistry processes are used to achieve polymer functionalization of GO, having limitations of high heterogeneity, time consumption, and difficult purification processes. T...
Breakdown into nanoscale of graphene oxide: Confined hot spot atomic reduction ...
Goncalves, Gil; Vila, Mercedes; Bdikin, Igor; de Andres, Alicia; Emami, Nazanin; Ferreira, Rute A. S.; Carlos, Luis D.; Gracio, JoseNano-graphene oxide (nano-GO) is a new class of carbon based materials being proposed for biomedical applications due to its small size, intrinsic optical properties, large specific surface area, and easy to functionalize. To fully exploit nano-GO properties, a reproducible method for its production is of utmost importance. Herein we report, the study of the sequential fracture of GO sheets onto nano-GO with co...