2 documents found, page 1 of 1
The Expression of Chemokines Is Downregulated in a Pre-Clinical Model of TTR V3...
Moreira, J; Costelha, S; Saraiva, M; Saraiva, MJMInflammation is a hallmark of several neurodegenerative disorders including hereditary amyloidogenic transthyretin amyloidosis (ATTRv). ATTRv is an autosomal dominant neurodegenerative disorder with extracellular deposition of mutant transthyretin (TTR) aggregates and fibrils, particularly in nerves and ganglia of the peripheral nervous system. Nerve biopsies from ATTRv patients show increased cytokine producti...
Delivery of an anti-transthyretin Nanobody to the brain through intranasal admi...
Gomes, JR; Cabrito, I; Soares, H; Costelha, S; Teixeira, A; Wittelsberger, A; Stortelers, C; Vanlandschoot, P; Saraiva, MJTransthyretin (TTR) is a transport protein of retinol and thyroxine in serum and CSF, which is mainly secreted by liver and choroid plexus, and in smaller amounts in other cells throughout the body. The exact role of TTR and its specific expression in Central Nervous System (CNS) remains understudied. We investigated TTR expression and metabolism in CNS, through the intranasal and intracerebroventricular delive...