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Enhanced role of adenosine A2A receptors in the modulation of LTP in the rat hi...
Costenla, Ana R.; Diógenes, Maria J.; Canas, Paula M.; Rodrigues, Ricardo J.; Nogueira, Célia; Maroco, João; Agostinho, Paula M.; Ribeiro, Joaquim A.Adenosine neuromodulation depends on a balanced activation of inhibitory A1 (A1R) and facilitatory A2A receptors (A2AR). Both A1R and A2AR modulate hippocampal glutamate release and NMDA-dependent long-term potentiation (LTP) but ageing affects the density of both A1R and A2AR. We tested the effects of selective A1R and A2AR antagonists in the modulation of synaptic transmission and plasticity in rat hippocampa...
Date: 2011
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Origin: Repositório do Ispa - Instituto Universitário