27 documents found, page 1 of 3
Oral Ang-(1-7) treatment improves white adipose tissue remodeling and hypertens...
Barbosa, Maria Andréa; Sousa, Graziele Galdino de; Castro, Uberdan Guilherme Mendes de; Carneiro, Cláudia Martins; Figueiredo, Vivian PaulinoObjective: Angiotensin (Ang)-(1-7) has preventive effects on metabolic syndrome (MetS). The aim of this study was to evaluate the therapeutic effect of oral Ang-(1-7) on mean arterial pressure (MAP), insulin resistance (IR), inflammatory process, and remodeling of white adipose tissue (WAT) in rats with establishedMetS. Methods: Rats were subjected to control (CT; AIN-93M) or high-fat (HF) diets for 13 wk to in...
Antioxidant effects of oral Ang-(1-7) restore insulin pathway and RAS component...
Figueiredo, Vivian Paulino; Barbosa, Maria Andréa; Castro, Uberdan Guilherme Mendes de; Zacarias, Aline Cruz; Bezerra, Frank SilvaIn prevention studies of metabolic syndrome (MetS), Ang-(1-7) has shown to improve the insulin signaling. We evaluated the HPβCD/Ang-(1-7) treatment on lipid metabolism, renin-angiotensin system (RAS) components, oxidative stress, and insulin pathway in the liver and gastrocnemius muscle and hepatic steatosis in rats with established MetS. After 7 weeks of high-fat (FAT) or control (CT) diets, rats were treated...
Alterations in the proteomic composition of Serratia marcescens in response to ...
Queiroz, Pollyana Santos; Ruas, France Anne Dias; Barboza, Natália Rocha; Borges, William de Castro; Cota, Renata Guerra de SáBackground: Proteomics is an important tool for the investigation of dynamic physiological responses of microbes under heavy metal stress. To gain insight into how bacteria respond to manganese (II) and identify the proteins involved in Mn (II) oxidation, the shotgun proteomics approach was applied to a potential Mn (II)-oxidizing Serratia marcescens strain cultivated in the absence and presence of Mn (II). Res...
Identification of 170 new long noncoding RNAs in Schistosoma mansoni.
Oliveira, Victor Fernandes de; Moraes, Lauro Ângelo Gonçalves de; Mota, Ester Alves; Passos, Liana Konovaloff Jannotti; Coelho, Paulo Marcos ZechLong noncoding RNAs (lncRNAs) are transcripts generally longer than 200 nucleotides with no or poor protein coding potential, and most of their functions are also poorly characterized. Recently, an increasing number of studies have shown that lncRNAs can be involved in various critical biological processes such as organism development or cancer progression. Little, however, is known about their effects in helmi...
High manganese tolerance and biooxidation ability of Serratia marcescens isolat...
Barboza, Natália Rocha; Morais, Mônica Mendes Cordeiro Araújo; Queiroz, Pollyana Santos; Amorim, Soraya Sander; Cota, Renata Guerra de Sáanganese is an important metal for the maintenance of several biological functions, but it can be toxic in high concentrations. One of the main forms of human exposure to metals, such as manganese (Mn), is the consumption of solar salt contaminated. Mn-tolerant bacteria could be used to decrease the concentration of this metal from contaminated sites through safer environmental-friendly alternative technology i...
Transcriptional profile and structural conservation of SUMO-Specific proteases ...
Pereira, Roberta Verciano; Cabral, Fernanda Janku; Gomes, Matheus de Souza; Passos, Liana Konovaloff Jannotti; Borges, William de CastroSmall ubiquitin-related modifier (SUMO) is involved in numerous cellular processes including protein localization, transcription, and cell cycle control. SUMOylation is a dynamic process, catalyzed by three SUMO-specific enzymes and reversed by Sentrin/SUMO-specific proteases (SENPs). Here we report the characterization of these proteases in Schistosoma mansoni. Using in silico analysis, we identified two SENPs...
Physical activity prevents alterations in mitochondrial ultrastructure and gluc...
Queiroz, Karina Barbosa de; Sampaio, Kinulpe Honorato; Rossoni Júnior, Joamyr Victor; Leal, Diego Andrade; Pinto, Angélica Barbosa GonçalvesEndurance exercise is a remarkable intervention for the treatment of many diseases. Mitochondrial changes on skeletal muscle are likely important for many of the benefits provided by exercise. In this study, we aimed to evaluate the effects that a regular physical activity (swimming without workload) has on mitochondrial morphological alterations and glucometabolic parameters induced by a high-sugar diet (HSD)....
Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome...
Cerqueira, Paula Gonçalves; Silva, Danielle Gomes Passos; Rocha, João Pedro Vieira da; Mendes, Isabela Cecilia; Oliveira, Karla Andrade detIn recent years, proteasome involvement in the damage response induced by ionizing radiation (IR)became evident. However, whether proteasome plays a direct or indirect role in IR-induced damageresponse still unclear. Trypanosoma cruzi is a human parasite capable of remarkable high tolerance toIR, suggesting a highly efficient damage response system. Here, we investigate the role of T. cruzi pro-teasome in the ...
Higher expression of CCL2, CCL4, CCL5, CCL21, and CXCL8 chemokines in the skin ...
Souza, Daniel Menezes; Cota, Renata Guerra de Sá; Carneiro, Cláudia Martins; Souza, Juliana Vitoriano de; Giunchetti, Rodolfo CordeiroBackground: The immune response in the skin of dogs infected with Leishmania infantum is poorly understood, and limited studies have described the immunopathological profile with regard to distinct levels of tissue parasitism and the clinical progression of canine visceral leishmaniasis (CVL). Methodology/Principal Findings: A detailed analysis of inflammatory cells (neutrophils, eosinophils, mast cells, lympho...
The impact of sequence length and number of sequences on promoter prediction pe...
Carvalho, Sávio Gonçalves; Cota, Renata Guerra de Sá; Merschmann, Luiz Henrique de CamposBackground: The advent of rapid evolution on sequencing capacity of new genomes has evidenced the need for data analysis automation aiming at speeding up the genomic annotation process and reducing its cost. Given that one important step for functional genomic annotation is the promoter identification, several studies have been taken in order to propose computational approaches to predict promoters. Different c...