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Leishmanicidal and Antimicrobial Activities of 4-Quinolone Alkaloids from Stems...
Silva,Raquel M.; Domingos,Levy T. S.; Castro,Gabriellen M. M. de; Laport,Marinella S.; Ferreira-Pereira,Antônio; Lima,Murilo M. C.; Cotinguiba,FernandoA chemical investigation of the stem of Waltheria indica (Malvaceae) yielded twelve 4-quinolone alkaloids, which were primarily waltheriones. These were waltherione A (1), waltherione B (2), waltherione C (3), waltherione G (4), waltherione H (5), waltherione J (6), waltherione L (7), waltherione P (8), chamaedrone (9), 8-deoxy-antidesmone (10), antidesmone (11), and the previously unreported alkaloid N-methoxy...
Trypanosoma cruzi: analysis of two different strains after piplartine treatment
Vieira,Gabriela Alves Licursi; Silva,Marco Túlio Alves da; Regasini,Luis Octávio; Cotinguiba,Fernando; Laure,Helen Julie; Rosa,José César; Furlan,MaysaABSTRACT The hemoflagellate protozoan, Trypanosoma cruzi, mainly transmitted by triatomine insects through blood transfusion or from mother-to-child, causes Chagas' disease. This is a serious parasitic disease that occurs in Latin America, with considerable social and economic impact. Nifurtimox and benznidazole, drugs indicated for treating infected persons, are effective in the acute phase, but poorly effecti...
Kavalactones and Benzoic Acid Derivatives from Leaves of Piper fuligineum Kunth...
Mazzeu,Bruna F.; Felippe,Lidiane G.; Cotinguiba,Fernando; Kato,Massuo J.; Furlan,MaysaThe known kavalactones (E)-4-methoxy-6-styryl-2H-pyran-2-one, 4-methoxy-6-(3-phenyloxiran-2-yl)-2H-pyran-2-one, 6-(1,2-dihydroxy-2-phenylethyl)-4-methoxy-2H-pyran-2-one, the three benzoic acid derivatives methyl-4-methoxy-3-(3'-methyl-2'-butenyl)benzoate and methyl 2,2-dimethyl-4-oxochroman-6-carboxylate, and a new methyl 4-methoxy-3-(3-methylbut-2-enoyl)benzoate were isolated from the ethanolic extract of Pipe...
Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor ...
Valli,Marilia; Altei,Wanessa; Santos,Ricardo N. dos; Lucca Jr.,Emilio C. de; Dessoy,Marco A.; Pioli,Renan M.; Cotinguiba,Fernando; Cachet,XavierPiperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable interest as an approach for discovering antimetastatic agents because this process is fundamental to metastasis. Piperlongumine, selected from cell-based assay screening of NuBBE Database, inh...
Trypanocidal activity of Piper arboreum and Piper tuberculatum (Piperaceae)
Regasini,Luis Octávio; Cotinguiba,Fernando; Passerini,Gabriela Duó; Bolzani,Vanderlan da Silva; Cicarelli,Regina Maria Barretto; Kato,Massuo JorgeIn the scope of our ongoing research on bioactive agents from Brazilian flora, twenty-four extracts and fractions obtained from Piper arboreum Aub. and Piper tuberculatum Jacq. (Piperaceae) were screened for trypanocidal activity by using MTT colorimetric assay. The strongest activity was found in hexane fractions from the leaves of P. arboreum (IC50= 13.3 µg/ mL) and P. tuberculatum (IC50 = 17.2 µg/mL). Hexane...