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Mucosal healing in ulcerative colitis – when zero is better

Carvalho, Pedro Boal; Castro, Francisca Dias de; Rosa, Bruno; Moreira, Maria João; Cotter, José de Almeida Berkeley

Background and aims: Extensive evidence has underlined the importance of mucosal healing as a treatment aim for ulcerative colitis (UC). We aimed to assess differences in the incidence of clinical relapse at 12 months between UC patients with Mayo endoscopic scores (MES) 0 and 1. Methods: This retrospective study included consecutive patients in corticosteroid-free remission between 2008 and 2013 and with follo...


PillCam® SB3 capsule: does the increased frame rate eliminate the risk of missi...

Monteiro, Sara; Castro, Francisca Dias de; Carvalho, Pedro Boal; Moreira, Maria João; Rosa, Bruno; Cotter, José de Almeida Berkeley

Since its emergence in 2000, small bowel capsule endoscopy (SBCE) has assumed a pivotal role as an investigation method for small bowel diseases. The PillCam (R) SB2-ex offers 12 h of battery time, 4 more than the previous version (SB2). Rahman et al recently found that the PillCam (R) SB2-ex has a significantly increased completion rate, although without higher diagnostic yield, compared with the SB2. We would...


Virtual chromoendoscopy improves the diagnostic yield of small bowel capsule en...

Carvalho, Pedro Boal; Magalhães, Joana; Castro, Francisca Dias de; Gonçalves, Tiago Cúrdia; Rosa, Bruno; Moreira, Maria João

Background: Small bowel capsule endoscopy represents the initial investigation for obscure gastrointestinal bleeding. Flexible spectral imaging colour enhancement (FICE) is a virtual chromoendoscopy technique designed to enhance mucosal lesions, available in different settings according to light wave-length - FICE1, 2 and 3. Aims: To compare the diagnostic yield of FICE1 and white light during capsule endoscopy...


Enteroscopia por cápsula e doença de Crohn: Caminhos para a otimização

Cotter, José de Almeida Berkeley

INTRODUÇÃO E OBJETIVOS: A videocápsula endoscópica permitiu avanços significativos no diagnóstico da patologia do intestino delgado, embora ainda existam limitações inerentes ao procedimento. Na doença de Crohn, com atingimento do intestino delgado, a enteroscopia por cápsula (EC) poderá desempenhar um papel importante não só no diagnóstico, mas também na objetivação da atividade inflamatória, podendo ainda rep...


Improving diagnostic yield in obscure gastrointestinal bleeding - how virtual c...

Castro, Francisca Dias de; Magalhães, Joana; Carvalho, Pedro Boal; Gonçalves, Tiago Cúrdia; Rosa, Bruno; Moreira, Maria João

Background and aim: A significant proportion of patients presenting with obscure gastrointestinal bleeding (OGIB) have negative small bowel capsule endoscopy (SBCE) examinations, and yet remain at risk of rebleeding. We aimed to evaluate whether a second-look review of SBCE images using flexible spectral color enhancement (FICE) may improve the detection of potentially bleeding lesions. Materials and methods: T...


Endoscopic retrograde cholangiopancreatography for suspected choledocholithiasi...

Cotter, José de Almeida Berkeley; Magalhães, Joana; Rosa, Bruno

AIM To study the practical applicability of the American Society for Gastrointestinal Endoscopy guidelines in suspected cases of choledocholithiasis. METHODS This was a retrospective single center study, covering a 4-year period, from January 2010 to December 2013. All patients who underwent endoscopic retrograde cholangiopancreatography (ERCP) for suspected choledocholithiasis were included. Based on the prese...


Lewis Score - Prognostic value in patients with isolated small bowel Crohn's di...

Castro, F. Dias de; Carvalho, Pedro Boal; Monteiro, Sara; Rosa, Bruno; Firmino-Machado, João; Moreira, Maria João; Cotter, José de Almeida Berkeley

Background and aims: Small bowel capsule endoscopy (SBCE) allows mapping of small bowel inflammation in Crohn’s disease (CD). We aimed to assess the prognostic value of the severity of inflammatory lesions, quantified by the Lewis score (LS), in patients with isolated small bowel CD. Methods: A retrospective study was performed in which 53 patients with isolated small bowel CD were submitted to SBCE at the time...


Validation of the Lewis score for the evaluation of small-bowel Crohn’s disease...

Cotter, José de Almeida Berkeley; Castro, Francisca Dias de; Magalhães, Joana; Moreira, Maria João; Rosa, Bruno

Background and study aims: The Lewis score was developed to measure mucosal inflammatory activity as detected by small-bowel capsule endoscopy (SBCE). The aim of the current study was to validate the Lewis score by assessing interobserver correlation and level of agreement in a clinical setting. Patients and methods: This was a retrospective, single-center, double-blind study including patients with isolated sm...


Small bowel capsule endoscopy in obscure gastrointestinal bleeding : normalcy i...

Gonçalves, Tiago Cúrdia; Castro, Francisca Dias de; Moreira, Maria João; Rosa, Bruno; Cotter, José de Almeida Berkeley

BACKGROUND/AIM: Small bowel capsule endoscopy (SBCE) is currently a fundamental tool in the etiological study of obscure gastrointestinal bleeding (OGIB). However, the impact of a negative exam and the risk of rebleeding are not entirely known. The aim of this study was to evaluate the outcomes of patients with OGIB and a negative SBCE examination in terms of follow-up duration, additional diagnostic studies, a...


Virtual chromoendoscopy in small bowel capsule endoscopy: new light or a cast o...

Cotter, José de Almeida Berkeley; Magalhães, Joana; Castro, Francisca Dias de; Barbosa, Mara; Carvalho, Pedro Boal; Leite, Sílvia; Moreira, Maria João

AIM: To evaluate whether virtual chromoendoscopy can improve the delineation of small bowel lesions previously detected by conventional white light small bowel capsule endoscopy (SBCE). METHODS: Retrospective single center study. One hundred lesions selected from forty-nine consecutive conventional white light SBCE (SBCE-WL) examinations were included. Lesions were reviewed at three Flexible Spectral Imaging Co...


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