3 documents found, page 1 of 1
Metabolic profiling of maternal urine can aid clinical management of gestationa...
Pinto, Joana; Diaz, Silvia O.; Aguiar, Elisabete; Duarte, Daniela; Barros, Antonio S.; Galhano, Eulalia; Pita, Cristina; Almeida, Maria do CeuIntroduction The clinical management of Gestational diabetes mellitus (GDM) would benefit from enhanced metabolic knowledge both at the time of diagnosis and during therapy. Objectives This work aimed at unveiling metabolic markers of GDM and of the subjects' response to therapy. Methods Urine NMR metabolomics was used with a variable selection methodology to reduce uninformative variability. The NMR data was a...
Newborn Urinary Metabolic Signatures of Prematurity and Other Disorders: A Case...
Diaz, Silvia O.; Pinto, Joana; Barros, Antonio S.; Morais, Elisabete; Duarte, Daniela; Negrao, Fatima; Pita, Cristina; Almeida, Maria do CeuThis work assesses the urinary metabolite signature of prematurity in newborns by nuclear magnetic resonance (NMR) spectroscopy, while establishing the role of possible confounders and signature specificity, through comparison to other disorders. Gender and delivery mode are shown to impact importantly on newborn urine composition, their analysis pointing out at specific metabolite variations requiring consider...
Metabolite Profiling of Human Amniotic Fluid by Hyphenated Nuclear Magnetic Res...
Graça, Gonçalo; Duarte, Iola F.; Goodfellow, Brian J.; Carreira, Isabel M.; Couceiro, Ana Bela; Domingues, Maria do Rosário; Spraul, ManfredThe metabolic profiling of human amniotic fluid (HAF) is of potential interest for the diagnosis of disorders in the mother or the fetus. In order to build a comprehensive metabolite database for HAF, hyphenated NMR has been used, for the first time, for systematic HAF profiling. Experiments were carried out using reverse-phase (RP) and ion-exchange liquid chromatography (LC), in order to detect less and more p...