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Development of a Healthy Lifestyle Assessment Toolkit for the General Public
Reis, Flávio; Sá-Moura, Bebiana; Guardado, Diana; Couceiro, Patrícia; Catarino, Luis; Mota-Pinto, Anabela; Veríssimo, Manuel T.; Teixeira, Ana MariaThe prevalence of age-related non-communicable chronic diseases has increased worldwide, being the leading causes of morbidity and death in many world regions, including in Europe. Innovative models and strategies focused on preventive care, including early identification of risk factors underlying disease onset and progression, and proper modification of lifestyle habits and behaviors, might contribute to prom...
NKT-Like (CD3+CD56+) Cells in Chronic Myeloid Leukemia Patients Treated With Ty...
Almeida, Jani Sofia; Couceiro, Patrícia; López-Sejas, Nelson; Alves, Vera; Růžičková, Lenka; Tarazona, Raquel; Solana, Rafael; Tavares, PauloTherapy with Tyrosine Kinase Inhibitors (TKI) aiming stable deep molecular response is the gold standard to treat Chronic Myeloid Leukemia (CML). NKT-like cells (CD3+CD56+) combine characteristics of T and NK cells. The physiopathological role of these cells remains unknown although the literature refers their association with inflammation, autoimmune diseases, and cancer. Since the information regarding the ro...
Bridging Health and Social Care with the Citizens – The Case of EIT Health Proj...
Sá-Moura, Bebiana; Couceiro, Patrícia; Catarino, Luis; Guardado, Diana; Brito, Maja de; Silva, Bárbara; Tavares, Rui; Ramalho-Santos, JoãoThe global burden of population ageing imposes the need of innovative care models and good practices to ensure the sustainability of health and social care support, as well as optimal quality of life of the citizens. Science and technology-based innovation is required to be cross-fertilized with co-creation strategies, involving different stakeholders and the citizens. Health literacy is a crucial component of ...
Effect of Age on NK Cell Compartment in Chronic Myeloid Leukemia Patients Treat...
Rodrigues-Santos, Paulo; López-Sejas, Nelson; Almeida, Jani-Sofia; Ruzičková, Lenka; Couceiro, Patrícia; Alves, Vera; Campos, Carmen; Alonso, CoronaNatural killer (NK) cells are a very important component of the innate immune response involved in the lysis of virus infected and tumor cells. Aging has a profound impact in the frequency, phenotype and function of NK cells. Chronic Myeloid Leukemia (CML) is caused by the BCR-ABL gene formation encoding aberrant oncoprotein tyrosine kinase. Treatment with tyrosine kinase inhibitors (TKIs) induces durable deep ...
Carcinoma epidermóide do pulmão: Polissomia e amplificação do cromossoma 7 e do...
Couceiro, Patrícia; Sousa, Vítor; Alarcão, Ana; Silva, Maria; Carvalho, LinaO receptor do factor de crescimento epidérmico (EGFR) está sobreexpresso na maioria dos carcinomas do pulmão de não pequenas células (CPNPC) e é um dos principais alvos específicos dos inibidores da tirosina cinase (TKI) utilizados para o tratamento do CPNPC avançado. Apesar disto, há um considerável número de factores biológicos que também estão associados à resposta dos EGFR-TKIs. Este estudo teve como princi...
Projecto de estadiamento do cancro do pulmão pela IASLC: Estudo comparativo ent...
Carvalho, Lina; Cardoso, Edgar; Nunes, Henrique; Baptista, Victor; Gomes, Ana; Couceiro, PatríciaA futura 7.ª edição TNM da Classificação de Tumores Malignos, a publicar em 2009, contempla várias recomendações estabelecidas pela IASLC para alterações nos componentes T, N e M, no que diz respeito ao estadiamento do cancro do pulmão. As alterações no estadiamento global dos doentes, que decorrem destas recomendações, incluem: a reclassificação de tumores com mais de 7cm de T2 para T3; a mudança de algumas ca...