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Transthyretin participates in beta-amyloid transport from the brain to the live...
Alemi, M; Gaiteiro, C; Ribeiro, C; Santos, L; Gomes, J; Oliveira, S; Couraud, P; Weksler, B; Romero, I; Saraiva, MJ; Cardoso, ITransthyretin (TTR) binds Aβ peptide, preventing its deposition and toxicity. TTR is decreased in Alzheimer’s disease (AD) patients. Additionally, AD transgenic mice with only one copy of the TTR gene show increased brain and plasma Aβ levels when compared to AD mice with both copies of the gene, suggesting TTR involvement in brain Aβ efflux and/or peripheral clearance. Here we showed that TTR promotes Aβ inter...
Date: 2016
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Origin: Repositório Aberto da Universidade do Porto