3 documents found, page 1 of 1
Mastocytosis presenting with mast cell-mediator release-associated symptoms eli...
Rama, TA; Morgado, JM; Henriques, A; Escribano, L; Alvarez-Twose, I; Sanchez-Muñoz, L; Moreira, A; Romão, J; Órfão, A; Matito, ABackground: Nonsteroidal anti-inflammatory drugs (NSAIDs) are frequently avoided in mastocytosis, because of a potential increased risk for drug hypersensitivity reactions (DHRs) due to inhibition of cyclo-oxygenase (COX), subsequent depletion of prostaglandin E2 and release of leukotrienes. Objectives: Here, we aimed at determining the prevalence of mast cell (MC) mediator release symptoms triggered by NSAIDs ...
Functional characterization of peripheral blood dendritic cells and monocytes i...
Henriques, A; Inês, L; Carvalheiro, T; Couto, M; Andrade, A; Pedreiro, S; Laranjeiro, P; Morgado, JM; Pais, ML; Pereira da Silva, JA; Paiva, AWith the purpose of contributing to a better knowledge of the APCs functional activity in SLE, we evaluated the distribution and functional ability to produce pro-inflammatory cytokines (TNF-α, IL-1β, IL-6 and IL-12) of peripheral blood (PB) monocytes and DC (tDC), particularly myeloid (mDC) and CD14(-/low)CD16(+) DC subpopulations comparing them with those obtained from healthy individuals. The study was perfo...
Contact sensitizers downregulate the expression of the chemokine receptors CCR6...
Cruz, MT; Gonçalo, Margarida; Paiva, A; Morgado, JM; Figueiredo, A; Duarte, CB; Lopes, MCChemokines are involved in the control of dendritic cell (DC) trafficking, which is critical for the immune response, namely in allergic contact dermatitis (ACD). In this work, we investigated by flow cytometry the effect of the contact sensitizers 2,4-dinitrofluorobenzene (DNFB), 1,4-phenylenediamine (PPD) and nickel sulfate (NiSO(4)), on the surface expression of the chemokine receptors CCR6 and CXCR4 in DC. ...