Encontrados 11 documentos, a visualizar página 1 de 2

Desenhar o espaço pelas ideias. O esquisso como fio condutor do projeto

Atualmente, na era do digital, o computador veio substituir a rotring, o que leva a questionar se a prática do esquisso é uma constante na práxis profissional, no campo disciplinar do design de interiores e da arquitetura. Esta dissertação investiga, sob o ponto de vista do projetista desenhador, cinco casos de estudo: os arquitetos João Mendes Ribeiro, Guilherme Machado Vaz, Désirée Pedro (Atelier do Corvo), F...

A designed cyclic analogue of gomesin has potent activity against Staphylococcu...

Background: Infections caused by bacterial biofilms are very difficult to treat. The use of currently approved antibiotics even at high dosages often fails, making the treatment of these infections very challenging. Novel antimicrobial agents that use distinct mechanisms of action are urgently needed. Objectives: To explore the use of [G1K,K8R]cGm, a designed cyclic analogue of the antimicrobial peptide gomesin...

Whole-genome DNA sequencing: the key to detecting a sarcomeric mutation in a ‘f...

The authors report the clinical and genetic investigation of a family with hypertrophic cardiomyopathy (HCM). The individuals described are three affected first-degree relatives (father, daughter and son), one affected niece and unaffected nephew and niece. Those affected all share a very similar phenotype consisting of asymmetric HCM, with hypertrophy particularly affecting the septum and the anterior wall, an...

Polineuropatia Periférica Desmielinizante: Implicações Anestésicas

A doença de Charcot-Marie-Tooth é uma polineuropatia periférica desmielinizante, caracterizada por fraqueza muscular distal, distúrbios motores e sensitivos e deformidades esqueléticas. Os principais desafios na abordagem anestésica destes doentes, relacionam-se com o uso adequado de relaxantes musculares e o risco de hipertermia maligna.  Mulher, 43 anos, ASA 3, proposta para cirurgia electiva de laqueação e s...

The mechanism of action of pepR, a viral-derived peptide, against Staphylococcu...

Objectives: To investigate the mechanism of action at the molecular level of pepR, a multifunctional peptide derived from the Dengue virus capsid protein, against Staphylococcus aureus biofilms. Methods: Biofilm mass, metabolic activity and viability were quantified using conventional microbiology techniques, while fluorescence imaging methods, including a real-time calcein release assay, were employed to inves...

Drug use in pregnant women of Mirandela, Macedo de Cavaleiros and Bragança

The use of drugs during the gestational period is a subject of great concern once the exposure of medicines may result in toxicities with possible irreversible lesions for fetus. In fact, drugs in pregnancy have been restricted since the accident of thalidomide. In 1979 the U.S. Food and Drug Administration (FDA) adopts the classification of drugs as the risk associated with their use during pregnancy, these be...

Language and speech disorders in kindergarten children study of prevalence and ...

Language and speech disorders in kindergarten children: study of prevalence and...

Life quality and the wellness in elderly. study case of the Casa do Menino Jesus

This research aims to present an analysis on the absence of innovative social responses to elderly, taking into account the need for stimulation of this population segment. Our main goal is not only a theoretical approach about the issue of elderly, but also present a study on the potentialities of the Casa do Menino Jesus, our case study, can apply for funding of a multisensorial stimulation response for elder...

Nutrição parentérica em contexto hospitalar: a pesagem das bolsas como método d...

A produção de nutrição parentérica está sujeita à ocorrência de erros colocando em risco a segurança do doente. O de controlo de qualidade da composição das bolsas produzidas em Farmácia Hospitalar torna-se indispensável de modo a contribuir para a minimização de erros, garantindo a qualidade final destas preparações. A pesagem das bolsas apresenta-se como um método de controlo de qualidade rápido, económico e ...