6 documents found, page 1 of 1
Early-onset autoimmune disease as a manifestation of primary immunodeficiency
Coutinho, Antonio
Early-Onset Autoimmune Disease as a Manifestation of Primary Immunodeficiency
Carneiro-Sampaio, Magda; Coutinho, AntonioAutoimmune disorders (AID) have been increasingly observed in association with primary immunodeficiencies (PIDs). Here, we discuss the interface between PID and AID, focusing on autoimmune manifestations early in life, which can be diagnostic clues for underlying PIDs. Inflammatory bowel disease in infants and children has been associated with IL-10 and IL-10R deficiencies, chronic granulomatous disease, immune...
Metabolic Adaptation to Tissue Iron Overload Confers Tolerance to Malaria
Gozzelino, Raffaella; Andrade, Bruno Bezerril; Larsen, Rasmus; Luz, Nívea Farias; Vanoaica, Liviu; Seixa, Elsa; Coutinho, AntonioTexto completo: acesso restrito. p. 693–704; Submitted by Edileide Reis (leyde-landy@hotmail.com) on 2014-05-06T17:00:53Z No. of bitstreams: 1 Manoel Barral Netto.pdf: 1535112 bytes, checksum: 511e0bbfefaaf21eb5c649bab7871771 (MD5); Approved for entry into archive by Flávia Ferreira (flaviaccf@yahoo.com.br) on 2014-10-21T16:43:41Z (GMT) No. of bitstreams: 1 Manoel Barral Netto.pdf: 1535112 bytes, checksum: 511e...
A Missing Dimension in Measures of Vaccination Impacts
Gomes, M. Gabriela M.; Lipsitch, Marc; Wargo, Andrew R.; Kurath, Gael; Rebelo, Carlota; Medley, Graham F.; Coutinho, Antonio
Increased IgE serum levels are unrelated to allergic and parasitic diseases in ...
Liphaus, Bernadete L.; Jesus, Adriana A.; Silva, Clovis A.; Coutinho, Antonio; Carneiro-Sampaio, MagdaOBJECTIVE: The aim of this study was to assess the IgE serum levels in juvenile systemic lupus erythematosus patients and to evaluate possible associations with clinical and laboratory features, disease activity and tissue damage. METHODS: The IgE serum concentrations in 69 consecutive juvenile systemic lupus erythematosus patients were determined by nephelometry. IgG, IgM and IgA concentrations were measured b...
The blind-spot of regulatory T cells
Graca, Luis; Silva-Santos, Bruno; Coutinho, AntonioCD4+ CD25+ Foxp3+ regulatory T cells (Treg) are natural suppressors of autoimmunity but they can also dampen the effective clearance of infectious organisms. These cells have the potential to be exploited to prevent transplant rejection and to treat autoimmune disease. A paper in this issue of the European Journal of Immunology details a method to selectively expand antigen-specific Treg from a polyclonal Treg ...