2 documents found, page 1 of 1
Severely impaired terminal erythroid differentiation as an independent prognost...
Ali, Abdullah Mahmood; Huang, Yumin; Pinheiro, Ronald Feitosa; Xue, Fumin; Hu, Jingping; Iverson, Nicholas; Hoehn, Daniela; Coutinho, DiegoAnemia is the defining feature in most patients with myelodysplastic syndromes (MDS), yet defects in erythropoiesis have not been well characterized. We examined freshly obtained bone marrow (BM) samples for stage-specific abnormalities during terminal erythroid differentiation (TED) from 221 samples (MDS, n = 205 from 113 unique patients; normal, n = 16) by measuring the surface expression of glycophorin A, ba...
Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...
Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteBackground Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...