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Characterization and Evaluation of Layered Bi2WO6 Nanosheets as a New Antibacte...

Leandro, MKDNS; Moura, JVB; Freire, PdTC; Vega, ML; Lima, CdL; Hidalgo, ÁA; Araújo, ACJ; Freitas, PR; Paulo, CLR; Sousa, AK; Rocha, JE; Leandro, LMG

Background: Pathogenic microorganisms are causing increasing cases of mortality and morbidity, along with alarming rates of ineffectiveness as a result of acquired antimicrobial resistance. Bi2WO6 showed good potential to be used as an antibacterial substance when exposed to visible light. This study demonstrates for the first time the dimension-dependent antibacterial activity of layered Bi2WO6 nanosheets. Mat...


Chalcones isolated from Arrabidaea brachypoda flowers as inhibitors of nora and...

Rezende-Júnior, LM; Andrade, LMS; Leal, ALAB; Mesquita, ABS; Santos, ALPA; Neto, JSL; Siqueira-Júnior, JP; Nogueira, CES; Kaatz, GW; Coutinho, HDM

Bacterial resistance to antibiotics has become a public health issue around the world. The present study aimed to evaluate the antibacterial activity of chalcones isolated from flowers of Arrabidaea brachypoda, and their potential as efflux pump inhibitors of Staphylococcus aureus efflux pumps. Microdilution assays were performed with natural products from A. brachypoda. Chalcones 1, 3, 4, and 5 did not show in...


Antioxidant, Antimicrobial, and Anticancer Effects of Anacardium Plants: An Eth...

Salehi, B; Gültekin-Özgüven, M; Kirkin, C; Özçelik, B; Morais-Braga, MFB; Carneiro, JNP; Bezerra, CF; Silva, TGd; Coutinho, HDM; Amina, B; Armstrong, L

Anacardium plants have received increasing recognition due to its nutritional and biological properties. A number of secondary metabolites are present in its leaves, fruits, and other parts of the plant. Among the diverse Anacardium plants' bioactive effects, their antioxidant, antimicrobial, and anticancer activities comprise those that have gained more attention. Thus, the present article aims to review the A...


In vitro toxicity, antioxidant, anti-inflammatory, and antidiabetic potential o...

Johnson, MAA; Madona, CX; Almeida, RS; Martins, N; Coutinho, HDM

Pteridophytes have been widely used in several systems of medicine. Several reports have increasingly assessed their bioactive effects, but for Sphaerostephanos unitus (L.) Holttum, only its antibacterial potential has been assessed. In this sense, the present study was carried out to reveal the phytochemical profile and to determine the toxicity, antioxidant, antidiabetic, and anti-inflammatory potential of S....


Structural, vibrational and electrochemical analysis and antibacterial potentia...

Silva, PT; Freitas, TS; Sena, DM; Bandeira, PN; Julião, MSdS; Marinho, ES; Alcanfor, AAC; Marinho, EM; Lima-Neto, P; Nogueira, CES; Coutinho, HDM

Background: Chalcones are part of a family of small phenolic compounds that are being extensively studied for presenting a diversity of molecular structures and biological activities. In this paper, two chalcones, (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(3-nitrophenyl)prop-2-en-1-one (1), (E)-1-(2-hydroxy-3,4,6-trimethoxyphenyl)-3-(4-nitrophenyl)prop-2-en-1-one (2), were synthesized by Claisen-Schmidt conden...


Ocotea glomerata (Nees) mez extract and fractions: Chemical characterization, a...

Anjos, MNV; Araújo-Neto, LN; Buonafina, MDS; Neves, RP; Souza, ER; Bezerra, ICF; Ferreira, MRA; Soares, LAL; Coutinho, HDM; Martins, N; Silva, MV

Background: Opportunistic fungal infections are increasingly common, with Candida albicans being the most common etiological agent; however, in recent years, episodes of candidiasis caused by non-albicans Candida species have emerged. Plants belonging to the Lauraceae family have shown remarkable antifungal effects. This study assessed the anti-Candida activity of Ocotea glomerata extracts and fractions, time o...


Evaluation of the antibacterial activity and efflux pump reversal of thymol and...

Sousa Silveira, Z; Macêdo, NS; Santos, JFS; Freitas, TS; Santos Barbosa, CR; Sousa, DL; Muniz, DF; Oliveira, LCC; Siqueira, JP; Cunha, FAB

The antibacterial activity and efflux pump reversal of thymol and carvacrol were investigated against the Staphylococcus aureus IS-58 strain in this study, as well as their toxicity against Drosophila melanogaster. The minimum inhibitory concentration (MIC) was determined using the broth microdilution method, while efflux pump inhibition was assessed by reduction of the antibiotic and ethidium bromide (EtBr) MI...


Anacardium plants: Chemical,nutritional composition and biotechnological applic...

Salehi, B; Gültekin-Özgüven, M; Kirkin, C; Özçelik, B; Morais-Braga, MFB; Carneiro, JNP; Bezerra, CF; Silva, TG; Coutinho, HDM; Amina, B; Armstrong, L

Anacardium plants are native to the American tropical regions, and Anacardium occidentale L. (cashew tree) is the most recognized species of the genus. These species contain rich secondary metabolites in their leaf and shoot powder, fruits and other parts that have shown diverse applications. This review describes the habitat and cultivation of Anacardium species, phytochemical and nutritional composition, and ...


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