11 documents found, page 1 of 2

Efeitos da radioterapia na pele e a intervenção da fisioterapia dermatofunciona...

Objetivo Esta revisão de literatura tem como objetivo identificar e descrever as alterações cutâneas provocadas pela RT, assim como evidenciar a intervenção da fisioterapia dermatofuncional no âmbito do seu tratamento em doentes oncológicos. Materiais e Métodos A pesquisa realizada decorreu entre os meses de Outubro e Dezembro de 2018, utilizando como bases de dados a PubMed e a ScienceDirect, sendo definido o ...

Distinct regulation of p53-mediated apoptosis by protein kinase calpha, delta, ...

The role of individual protein kinase C (PKC) isoforms in the regulation of p53- mediated apoptosis is still uncertain. Using yeast cells co-expressing the human wild-type p53 and a single mammalian PKCa, d, e or z, we showed a differential regulation of p53- mediated apoptosis by these PKC isoforms. Whereas PKCa and z had no effect on p53 activity, PKCd and e stimulated a p53-mediated mitochondria-dependent ap...

Aspartic vinyl sulfones: inhibitors of a caspase-3-dependent pathway

In this article we describe an expanded structureeactivity relationship study for vinyl sulfones as caspase-3 inhibitors, a topic virtually unexplored in the existing literature. Most remarkably, and to our surprise, tripeptidyl vinyl sulfones were not active for caspase-3, opposite to other examples described in literature for peptidyl vinyl sulfones as potent cysteine protease inhibitors of clan CA. Moreover,...

Intermittent claudication and physical exercise: effectiveness of a home-based ...

Peripheral arterial disease (PAD) has a high incidence in the general population and 12% to 20% of the population with more than 60 years has already clinical symptoms, such as intermittent claudication (IC), pain, loss of strength, and functional incapacity. There are already some studies that suggest the possible positive effects of physical exercise on the functional consequences of PAD. The purpose of this ...

Selective activation of protein kinase C-δ and -ɛ by 6,11,12,14-tetrahydroxy-ab...

6,11,12,14-tetrahydroxy-abieta-5,8,11,13-tetraene-7-one (coleon U) is a diterpene compound isolated from Plectranthus grandidentatus with an antiproliferative effect on several human cancer cell lines. Herein, we studied the modulatory activity of coleon U on individual isoforms of the three protein kinase C (PKC) subfamilies, classical (cPKC-α and -βI), novel (nPKC-δ and -ɛ) and atypical (aPKC-ζ), using a yeas...

VINYL SULFONES AS CASPASE INHIBITORS

Novel caspase-3 inhibitors based on a benzoyl scaffold

Contribution to the adaptation and validation of the Portuguese version of Moto...

Introduction: The Motor Assessment Scale (MAS) has been shown to be a valid and reliable instrument for measuring the clinical progress of stroke patients. Objectives: Translate and adapt the MAS to the Portuguese reality and contribute to the validation of the Portuguese version, by assessing its internal consistency. Methods: The  Portuguese version of the MAS was obtained through a process of translation, ex...

Evaluation of the grip force, lower body strength and functional capacity in ac...

Background - The practice of regular physical activity has a better impact on the global physical condition of elderly people.  Purpose - The mentoring of this study is to analyze if the practice of regular physical activity has any influence on the grip force, lower body strength, and functional capacity of the inhabitants of the Loures district aged over 60. Methods - A questionnaire was applied to a sel...

Factors of non-adherence to the exercise component of cardiac rehabilitation pr...

Background - Low attendance to Cardiac Rehabilitation programs is a current problem. Although there are several studies on the factors influencing the patients’ attendance to these programs, the professionals’ views on this subject are not known. Objectives - To identify factors of non-adherence to the exercise component of Cardiac Rehabilitation programs, according to physiotherapists. To verify if their opini...