133 documents found, page 1 of 14
Solubility of olive oil phenolic compounds in green solvents
Vale, Mariana Ribeiro de Paula; Zambom, Aline; Krüger, Felipe; Martins, Mónia A. R.; Coutinho, João A.P.; Pinho, Simão; Peres, António M.Olive oil production yields by-products rich in bioactive phenolics with potential uses in several types of industries
Solubility of olive oil phenolic compounds in green solvents
Vale, Mariana Ribeiro de Paula; Zambom, Aline; Krüger, Felipe; Martins, Mónia A. R.; Coutinho, João A.P.; Pinho, Simão; Peres, António M.The production of olive oil generates various by-products that are rich in phenyl alcohols, secoiridoids, phenolic acids and aldehydes, flavonoids, and other bioactive compounds. Due to their diverse biological activities, these compounds have promising potential as functional additives in the food, pharmaceutical, and cosmetics industries.1 However, data on their solubility in water and common volatile organic...
IN PRESS - Solvent screening for the purification of monoterpenoids by counterc...
Vilas‐Boas, Sérgio M.; Coutinho, João A.P.; Pinho, Simão; Ferreira, OlgaCountercurrent chromatography (CCC) and centrifugal partition chromatography (CPC) are efficient techniques to purify terpenoids from essential oils. These methods require suitable solvent systems for the partition between the two immiscible liquid phases. In this study, using the analytical shake-flask method, we measured the partition coefficients of three model monoterpenoids, namely carvone, eucalyptol and ...
Using Molecular Conformers in COSMO-RS to Predict Drug Solubility in Mixed Solv...
Cordova, Isabella Weber; Teixeira, Gabriel; Ribeiro-Claro, Paulo J.A.; Abranches, Dinis O.; Pinho, Simão; Ferreira, Olga; Coutinho, João A.P.This work explores the impact of solute conformers on the conductor-like screening model for real solvents (COSMO-RS) solubility predictions of vanillin and ethyl vanillin in water, short alcohols, and their mixed solvents. Two major conformers of these solutes and changes with solvent polarity were experimentally established by Raman spectroscopy and further confirmed by density functional theory calculations....
Designing type V deep eutectic solvents with antimalarial pharmaceutical ingred...
Teixeira, Gabriel; Brandão, Paula; Ferreira, Ana I.M.C. Lobo; Abranches, Dinis O.; Santos, L.uís M.N.B.F.; Ferreira, Olga; Coutinho, João A.P.This work studies the formation of deep eutectic solvents formed by one active pharmaceutical ingredient (quinine, pyrimethamine, or 2-phenylimidazopyridine) and a second component potentially acting as an excipient (betaine, choline chloride, tetramethylammonium chloride, thymol, menthol, gallic acid, vanillin, acetovanillone, 4-hydroxybenzaldehyde, syringaldehyde, propyl gallate, propylparaben, or butylated h...
Enhanced Antimalarial Activity of Extracts of Artemisia annua L. Achieved with ...
Ferreira, Ana M.; Sales, Isabela; Santos, Sónia A.O.; Santos, Tiago; Nogueira, Fátima; Mattedi, Silvana; Pinho, Simão; Coutinho, João A.P.Artemisinin, a drug used to treat malaria, can be chemically synthesized or extracted from Artemisia annua L. However, the extraction method for artemisinin from biomass needs to be more sustainable while maintaining or enhancing its bioactivity. This work investigates the use of aqueous solutions of salts and ionic liquids with hydrotropic properties as alternative solvents for artemisinin extraction from Arte...
What is better to enhance the solubility of hydrophobic compounds in aqueous so...
Ferreira, Olga; Silva, Liliana P.; Almeida, Heloísa H.S.; Benfica, Jordana; Abranches, Dinis O.; Pinho, Simão; Coutinho, João A.P.The solubilities of benzoic acid, (S)-hesperetin, and L-tryptophan in aqueous solutions of ionic liquids (choline glycolate and choline malonate) and the analogous eutectic solvents (choline chloride:glycolic acid and choline chloride:malonic acid) were studied. It is shown that while ionic liquids (IL) and eutectic solvents (ES) were able to increase the solubility of all compounds studied in aqueous solution,...
Deterpenation of citrus essential oil via extractive distillation using imidazo...
Vilas-Boas, Miguel; Batista, Fábio R.M.; Dias, Rafael M.; Coutinho, João A.P.; Ferreira, Olga; Costa, Mariana C.; Pinho, SimãoThe deterpenation of citrus essential oils (CEO) is crucial in many industries to promote the stability and preserve the organoleptic properties of the final product, improving considerably the oxygenated fraction purity. Methods: Two imidazolium ionic liquids (ILs), [C4mim][OAc] and [C4mim]Cl, were applied as novel separation agents in a deterpenation process constituted by an extractive distillation column an...
Salt effects on the solubility of aromatic and dicarboxylic amino acids in water
Aliyeva, Mehriban; Brandão, Paula; Gomes, José R.B.; Coutinho, João A.P.; Held, Christoph; Ferreira, Olga; Pinho, SimãoThe salt effect on the solubility of the amino acids L-aspartic acid, L-glutamic acid, L-tryptophan, and L-tyrosine, seldomly found in the literature, was studied at 298.2 K, in aqueous solutions of KCl and (NH4)2SO4, for salt concentrations up to 2.0 mol⋅kg -1. In this concentration range, both salts are salting-in agents for glutamic acid and aspartic acid, with a stronger effect induced by (NH4)2SO4. Regardi...
Solubilities of Amino Acids in the Presence of Chaotropic Anions
Aliyeva, Mehriban; Brandão, Paula; Coutinho, João A.P.; Ferreira, Olga; Pinho, SimãoThis work addresses the effect of chaotropic anions (thiocyanate and tosylate) on the solubility of glycine, L-leucine, L-phenylalanine, and L-aspartic acid in aqueous solutions at 298.2 K. The salts used were NaSCN, KSCN, NH4SCN, and NaC7H7SO3 (sodium tosylate), with salt concentrations ranging from 0 to 2 molal. The pH of the saturated solutions was registered, and solid-phase studies were also performed. All...