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Endoscopic sleeve gastroplasty: early results of a minimally invasive procedure...

Correia, Vítor Patrício; Maria, Bernardo; Paulino, Ana; Ferreira, Carlos; Costa Gomes, Olavo; Nogueira, Filipa; Chiado, António; Coutinho, Joao

Objectives: We aimed to analyze the efficacy and safety of endoscopic sleeve gastroplasty at 3 months as well as to determine factors influencing post-procedural weight loss. Methods: Seventy-three patients with obesity classes I, II and III (BMI 31.1-46.6 kg/m2) underwent ESG between September 2021 and April 2022 at a tertiary care hospital using Overstitch (Apollo Endosurgery, Austin, TX). ESG's efficacy and ...


Genetic and microenvironmental intra-tumor heterogeneity impacts colorectal can...

Sobral, Daniel; Martins, Marta; Kaplan, Shannon; Golkaram, Mahdi; Salmans, Michael; Khan, Nafeesa; Vijayaraghavan, Raakhee; Casimiro, Sandra

Colorectal cancer (CRC) is a highly diverse disease, where different genomic instability pathways shape genetic clonal diversity and tumor microenvironment. Although intra-tumor heterogeneity has been characterized in primary tumors, its origin and consequences in CRC outcome is not fully understood. Therefore, we assessed intra- and inter-tumor heterogeneity of a prospective cohort of 136 CRC samples. We demon...


Pancreas angiosarcoma : case report of a rare cause of abdominal pain

Faria, Aldara; Alpoim Lopes, Filipe; Figueira, Alberto; Miranda, Carlos; Coutinho, Joao

Introduction: Pancreas angiosarcoma is a very aggressive malignant neoplasm. The symptoms are nonspecific and it is usually diagnosed at an advanced stage, which confers a poor prognosis. Presentation of case: We present a 56-year-old woman with abdominal epigastric pain and nausea. The abdominal CT-scan showed a 7 cm mass within the head of the pancreas and the pathology and immunochemistry analysis were posit...


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