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External Validation of the SINCALC Score for Outcomes Following Cerebral Venous...

Klein, Piers; Shu, Liqi; Lindgren, Erik; de Winter, Maria A; Siegler, James E; Simpkins, Alexis N; Omran, Satareh Salehi; Heldner, Mirjam R

Objectives: Prognostication for cerebral venous thrombosis (CVT) remains difficult. We sought to validate the SI2NCAL2C score in an international cohort. Materials and methods: The SI2NCAL2C score was originally developed to predict poor outcome (modified Rankin Scale (mRS) 3-6) at 6 months, and mortality at 30 days and 1 year using data from the International CVT Consortium. The SI2NCAL2C score uses 9 variable...


Recanalization after cerebral venous thrombosis : a randomized controlled trial...

Ferro, José; Bendszus, Martin; Jansen, Olav; Coutinho, Jonathan M; Dentali, Francesco; Kobayashi, Adam; de Sousa, Diana Aguiar; Lucas Neto, Lia

Background: The effect of different anticoagulants on recanalization after cerebral venous thrombosis has not been studied in a randomized controlled trial. Methods: RE-SPECT CVT (ClinicalTrials.gov number: NCT02913326) was a Phase III, prospective, randomized, parallel-group, open-label, multicenter, exploratory trial with blinded endpoint adjudication. Acute cerebral venous thrombosis patients were allocated ...


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