3 documents found, page 1 of 1
Solute carriers affect Anopheles stephensi survival and Plasmodium berghei infe...
Couto, J.; Antunes, S.; Pinheiro-Silva, R.; Do Rosário, V.; De La Fuente, J.; Domingos, A.Malaria is caused by mosquito-borne Plasmodium spp. parasites that must infect and survive within mosquito salivary glands (SGs) prior to host transmission. Recent advances in transcriptomics and the complete genome sequencing of mosquito vectors have increased our knowledge of the SG genes and proteins involved in pathogen infection and transmission. Membrane solute carriers are key proteins involved in drug t...
Reduction of mosquito survival in mice vaccinated with Anopheles stephensi gluc...
Couto, J.; Antunes, S.; Ferrolho, J.; De La Fuente, J.; Domingos, A.Despite the fact that recent efforts to control/eradicate malaria have contributed to a significant decrease in the number of cases and deaths, the disease remains a global health challenge. Vaccines based on mosquito salivary gland antigens are a potential approach for reducing vector populations and malaria parasites. The Anopheles AGAP007752 gene encodes for a glucose transporter that is upregulated during P...
The Anopheles gambiae transcriptome – a turning point for malaria control
Domingos, A.; Pinheiro-Silva, R.; Couto, J.; do Rosário, V.; de la Fuente, J.Mosquitoes are important vectors of several pathogens and thereby contribute to the spread of diseases, with social, economic and public health impacts. Amongst the approximately 450 species of Anopheles, about 60 are recognized as vectors of human malaria, the most important parasitic disease. In Africa, Anopheles gambiae is the main malaria vector mosquito. Current malaria control strategies are largely focus...