5 documents found, page 1 of 1
A Study Protocol for Development and Validation of a Clinical Prediction Model ...
Apóstolo, J; Bobrowicz-Campos, E; Moreno-Casbas, T; Teixeira-Santos, L; Sánchez de Madariaga, R; Casado-Ramírez, E; Couto, F; Coelho, A; Parola, VítorThere is a growing need to implement and evaluate the technological solutions that allow the early detection of age-related frailty and enable assessment of the predictive values of frailty components. The broad use of these solutions may ensure an efficient and sustainable response of health and social care systems to the challenges related to demographic aging. In this paper, we present the protocol of the Mo...
A disfunção dopaminérgica mesolímbica na psicose: uma revisão da literatura
Moura, P; Couto, F; Abreu, M; Vian, J; Moura, T; Frade, P; Levy, PIntrodução: Desde há algumas décadas que se pensa que uma hiperactividade dopaminérgica da via mesolímbica esteja implicada na génese dos sintomas positivos da esquizofrenia. Objectivos: Nesta revisão da literatura procurámos interligar as várias áreas do conhecimento actual, procurando fazer a ponte com a prática clínica. Métodos: Foi efectuada uma pesquisa sistemática da literatura em inglês, até Abril de 201...
Decrease in APP and CP mRNA expression supports impairment of iron export in Al...
Guerreiro, C; Silva, B; Crespo, A; Marques, L; Costa, S; Timóteo, A; Marcelino, E; Maruta, C; Vilares, A; Matos, M; Couto, F; Faustino, P; Verdelho, AAlzheimer's disease (AD) is a neurodegenerative disorder of still unknown etiology and the leading cause of dementia worldwide. Besides its main neuropathological hallmarks, a dysfunctional homeostasis of transition metals has been reported to play a pivotal role in the pathogenesis of this disease. Dysregulation of iron (Fe) metabolism in AD has been suggested, particularly at the level of cellular iron efflux...
Crosstalk between genetics, gene expression and biochemical markers supports sy...
Crespo, A; Silva, B; Ferreira, C; Marquesa, L; Marcelino, E; Maruta, C; Costa, S; Timóteo, A; Vilares, A; Couto, F; Faustino, P; Correia, AP
Genetic and biochemical markers in patients with Alzheimer's disease support a ...
Crespo, A; Silva, B; Marques, L; Marcelino, E; Maruta, C; Costa, S; Timóteo, A; Vilares, A; Couto, F; Faustino, P; Correia, AP; Verdelho, A; Porto, GAlzheimer's disease (AD) is the most common form of dementia in the elderly individuals, resulting from a complex interaction between environmental and genetic factors. Impaired brain iron homeostasis has been recognized as an important mechanism underlying the pathogenesis of this disease. Nevertheless, the knowledge gathered so far at the systemic level is clearly insufficient. Herein, we used an integrative ...