31 documents found, page 1 of 4
Characterization of Staphylococcus aureus CC1 and CC1660 of Human and Equine Or...
Jahnen, Johanna; Cuny, Christiane; Witte, Wolfgang; Ehricht, Ralf; Monecke, Stefan; Hanke, Dennis; Ahrens, Tanja; Leal, Marta; Costa, Sofia S.Background/Objectives: Staphylococcus aureus isolates from humans and horses of the equine-associated clonal complexes (CCs) CC1 and CC1660 were comparatively investigated for their genomic relationships. Methods: A total of 91 S. aureus isolates (64 human, 27 equine) were subjected to whole-genome sequencing (WGS), sequence analysis, and antimicrobial susceptibility testing. Results: WGS confirmed 75 CC1 and 1...
Genomic analysis of the Staphylococcus pseudintermedius mobilome associated wit...
Morais, Catarina; Costa, Sofia Santos; Hanke, Dennis; Santos, Ana; Krüger-Haker, Henrike; Pomba, Constança; Feßler, Andrea T.; Schwarz, StefanThe increasing antimicrobial resistance (AMR) in Staphylococcus pseudintermedius causing skin and soft-tissue infections (SSTIs) in companion animals is a public health concern. The aim of this study was to verify if mobile genetic elements (MGEs), in particular plasmids, are related to the carriage of AMR genes among circulating and clinically relevant S. pseudintermedius. In total, 56 S. pseudintermedius, rep...
The impact of efflux on reduced susceptibility to biocides and fluoroquinolone ...
Leal, Marta; Pomba, Constança; Morais, Catarina; Costa, Sofia Santos; Ramos, Bárbara; Couto, Isabel; Abrantes, PatríciaStaphylococcus pseudintermedius is the main bacterial agent causing skin and soft tissue infections (SSTIs) in companion animals. The increasing resistance to antimicrobial compounds, associated with multidrug resistance phenotypes, poses a risk for the therapeutic control of skin infections caused by this pathogenic agent. Until now, efflux as a resistance mechanism has been overlooked for this species. The ai...
Building a Lusophone Network of Biobanks and Biological Collections: opportunit...
Arez, Ana Paula; Couto, Isabel; Belo, SilvanaBiobanks and Biological Collections serve as central infrastructures for fundamental to scientific research and innovation, supporting various scientific fields, such as the preservation of biodiversity, food sciences or biotechnology, and particularly biomedical research. They provide essential resources for innovation and translation in global health, particularly for the development of new biomarkers, therap...
Empowering portuguese-speaking women inTropical Health sciences:the journey of ...
Maurício, Isabel L.; Domingos, Ana; Arez, Ana Paula; Conceição, Cláudia; Couto, Isabel; Oliveira Martins, Maria do Rosário; Campino, LeneaFemale participation in science, including biomedical sciences, has increased, but still presents various challenges. The MulhereSTrop network was launched in 2015 to support women scientists in African Portuguese speaking countries (PALOP) inTropical Health.The network has offered workshops on scientific writing and has encouraged scientific article submission, with awards for the best. Through the website, th...
Virulence potential of biofilm-producing Staphylococcus pseudintermedius, Staph...
Andrade, Mariana; Oliveira, Ketlyn; Morais, Catarina; Abrantes, Patrícia; Pomba, C.; Rosato, Adriana E.; Couto, Isabel; Costa, Sofia SantosABSTRACT . Coagulase-positive staphylococci (CoPS) account for most bacteria-related pyoderma in companion animals. Emergence of methicillin-resistant strains of Staphylococcus pseudintermedius (MRSP), Staphylococcus aureus (MRSA) or Staphylococcus coagulans (MRSC), often with multidrugresistant (MDR) phenotypes, is a public health concern. The study collection comprised 237 staphylococci (S. pseudintermedius (...
Staphylococcus aureus causing skin and soft tissue infections in companion anim...
Costa, Sofia Santos; Rute, Ribeiro; Serrano, Maria; Oliveira, Ketlyn; Ferreira, Carolina; Leal, Marta; Pomba, C.; Couto, IsabelABSTRACT - Staphylococcus aureus is a relevant agent of skin and soft tissue infections (SSTIs) in animals. Fifty-five S. aureus comprising all SSTI-related isolates in companion animals, collected between 1999 and 2018 (Lab 1) or 2017 and 2018 (Lab 2), were characterized regarding susceptibility to antibiotics and heavy metals and carriage of antimicrobial resistance determinants. Clonal lineages were establis...
Proposal of epidemiological cutoff values for Apramycin 15 μg and Florfenicol 3...
Costa, Sofia Santos; Ferreira, Carolina; Ribeiro, Rute; Fessler, Andrea T.; Schink, Anne-Kathrin; Kadlec, Kristina; Kaspar, Heike; Amaro, AnaApramycin and florfenicol are two antimicrobial agents exclusively used in veterinary medicine. Resistance determinants to these antimicrobial agents have been described in several staphylococci, yet no inhibition zone-based epidemiological cutoff (ECOFF) values are available to detect populations harboring resistance mechanisms. In this study, we propose disk diffusion inhibition zone ECOFF values of Staphyloc...
Comunidade Formativa do Estoril: uma comunidade de prática centrada no internat...
Sá, Vanessa; Coutinho, Magda; Póvoa, Ana; Medeiros, Rita; Santos, Joana; Biscaia, André; Couto, IsabelIntrodução: Uma comunidade de prática consiste num grupo de pessoas que se unem em torno de um mesmo tópico ou interesse, trabalhando em conjunto para melhorar o que fazem através de interações regulares. A Comunidade Formativa do Estoril reúne o grupo de orientadores e internos de medicina geral e familiar e saúde pública da zona do Estoril, com o objetivo de alargar o seu leque de experiências e vivências, es...
Using genomics to understand the origin and dispersion of multidrug and extensi...
Perdigão, João; Gomes, Pedro; Miranda, Anabela; Maltez, Fernando; Machado, Diana; Silva, Carla; Phelan, Jody E.; Brum, Laura; Campino, SusanaPortugal is a low incidence country for tuberculosis (TB) disease. Now figuring among TB low incidence countries, it has since the 1990s reported multidrug resistant and extensively drug resistant (XDR) TB cases, driven predominantly by two strain-types: Lisboa3 and Q1. This study describes the largest characterization of the evolutionary trajectory of M/XDR-TB strains in Portugal, spanning a time-period of two...