15 documents found, page 1 of 2

Activation of nuclear receptors correlates with tuberculosis severity and is a ...

Introduction: The immune response to Mycobacterium tuberculosis is accompanied by metabolic adaptations that fuel host immunity, but that are exploited by the pathogen to ensure persistence and growth. Activation of nuclear receptors, such as liver-X-receptors (LXR), orchestrate macrophage immunometabolic adaptations to infection and globally associate with tuberculosis (TB) protection. Methods: We interrogated...

Provoking Value Reflection through Play and Speculative Design

The design of technology is shaped by human values, which may be either explicitly expressed or implicitly embedded within artefacts. While design methodologies and technology assessment frameworks aim to produce technologies that align with users’ needs—and, by extension, their values—they frequently prioritise usability and seamless interaction, often at the expense of critical reflection on the human values ...

Synergistic Gains in Mergers and Acquisitions: Case Study

The impact of mergers and acquisitions on organizational restructuring processes is particularly clear in the contemporary economy. Mergers and acquisitions can be seen as one of the main ways of generating profits for participating companies, as well as accessing new market opportunities. The objective of this article is to study of synergistic gains resulting from mergers and acquisitions activities. The sele...

Genetic Architecture of Congenital Hypogonadotropic Hypogonadism: Insights from...

Study question: What is the contribution of genetic defects in Portuguese patients with congenital hypogonadotropic hypogonadism (CHH)? Summary answer: Approximately one-third of patients with CHH were found to have a genetic cause for their disorder, with causal pathogenic and likely pathogenic germline variants distributed among 10 different genes; cases of oligogenic inheritance were also included. What is k...

The production of Maria do Carmo Barros Leite´s (1841-1911) information and its...

In the universe of archives, internationally and nationally, the production and conservation of female information is less studied, mainly because its existence is quantitatively lower or because it is not very visible. The present article has as a case study the informational system of Maria do Carmo Barros Leite (1841-1911), Teófilo Braga´s wife, former president of the Portuguese Republic. Through this case ...

Workshop on Implementation of Stakeholder Engagement Strategy (WKSTIMP)

WKSTIMP supports the ICES Stakeholder Engagement Strategy, through drafting elements for ICES Implementation Plan. The report defines a suit of actions to make the ICES Strategy work. If implemented successfully, a diverse and representative pool of competent, reliable and committed stakeholders will engage with ICES. All stakeholders will be able to contribute effectively based on a clear understanding of the ...

Motivações, preferências e práticas dos consumidores de produtos agroalimentare...

Rural Ties and Consumption of Rural Provenance Food Products - Evidence from th...

Consumers’ food preferences increasingly meet concerns of authenticity, health, origin, and sustainability, altogether attributes embodied in rural provenance food products. The dynamics of production, commercialization, and availability of these products in urban centers are growing stronger. This study aims to explore rural provenance food consumption and underlying motivations, the consumers’ images of produ...

Comparative Proteomic Analysis of Rhipicephalus sanguineus sensu lato (Acari: I...

Made available in DSpace on 2021-06-25T10:52:35Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-01-29; Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Fundação para a Ciência e a Tecnologia; The tick vector Rhipicephalus sanguineus is established as a c...

Fragaria vesca L. Extract: A Promising Cosmetic Ingredient with Antioxidant Pro...

Fragaria vesca L. (F. vesca), popularly known as wild strawberry, is a plant from the Rosaceae family, found in temperate and subtropical areas of the northern hemisphere. F. vesca leaves have been shown to have antiseptic, emollient, and dermatological protection properties, due to the presence of bioactive compounds, such as flavonoids, phenolic acids, ellagitannins, and proanthocyanidins. In this study, a F....