3 documents found, page 1 of 1
Berberine-induced cardioprotection and Sirt3 modulation in doxorubicin-treated ...
Coelho, Ana R.; Martins, Tatiana R.; Couto, Renata; Deus, Cláudia; Pereira, Cláudia V.; Simões, Rui F.; Rizvanov, Albert A.; Silva, FilomenaDoxorubicin (DOX) is one of the most widely used anti-neoplastic agents. However, treatment with DOX is associated with cumulative cardiotoxicity inducing progressive cardiomyocyte death. Sirtuin 3 (Sirt3), a mitochondrial deacetylase, regulates the activity of proteins involved in apoptosis, autophagy and metabolism. Our hypothesis is that pharmacological modulation by berberine (BER) pre-conditioning of Sirt3...
β-adrenergic over-stimulation and cardio-myocyte apoptosis: two receptors, one ...
Branco, Ana F.; Moreira, Ana C.; Cunha-Oliveira, Teresa; Couto, Renata; Sardão, Vilma A.; Rizvanov, Albert A.; Palotas, Andras; Oliveira, Paulo J.Neuro-hormonal regulation of cardiac function via cathecol-amines results in increased heart rate and contractility. A persistent adrenergic tone, however, is an insult to the heart, affecting its regular homeostasis, altering morphology and gene expression patterns, as well as inducing apoptosis of cardio-myocytes. At the same time as being the main oxygen consumers, mitochondria are also key to the energy pro...
Immune response and neutralization capacity of antibodies produced in young she...
Ferreira Junior, Rui Seabra; Nascimento, Nanci do; Couto, Renata; Alves, Janaína Baptista; Meira, Domingos Alves; Barraviera, BeneditoThe ELISA technique was used to evaluate and compare young ovine humoral immune response during crotalic antiserum production. Animals were clinically evaluated throughout this process, and the neutralizing capacity of antisera raised against natural (NV) and Cobalt-60 irradiated (IrV) venoms of Crotalus durissus terrificus (C.d.t.) was verified by means of in vitro challenges. Three groups of six animals each ...