8 documents found, page 1 of 1
Female Voice-Related Sexual Attractiveness to Males: Does it Vary With Differen...
Lã, Filipa M. B.; Polo, Nuria; Granqvist, Svante; Cova, Tânia; Pais, Alberto C.Previous investigations have found that female voice-related attractiveness to males increases when both conception likelihood (CL) and voice fundamental frequency (fo) are elevated. To test this hypothesis, we conducted a perceptual experiment where 78 heterosexual males rated sexual attractiveness of 9 female voice samples, recorded at menstrual, follicular and luteal phases of the menstrual cycle under two d...
A Stepwise Framework for the Systematic Development of Lipid Nanoparticles
Basso, João; Mendes, Maria; Cova, Tânia; Sousa, João; Pais, Alberto; Fortuna, Ana; Vitorino, Rui; Vitorino, CarlaA properly designed nanosystem aims to deliver an optimized concentration of the active pharmaceutical ingredient (API) at the site of action, resulting in a therapeutic response with reduced adverse effects. Due to the vast availability of lipids and surfactants, producing stable lipid dispersions is a double-edged sword: on the one hand, the versatility of composition allows for a refined design and tuning of...
Female Voice-Related Sexual Attractiveness to Males: Does it Vary With Differen...
Lã, Filipa M.B.; Polo, Nuria; Granqvist, Svante; Cova, Tânia; Pais, Alberto C.In Press, Corrected Proof; Previous investigations have found that female voice-related attractiveness to males increases when both conception likelihood (CL) and voice fundamental frequency (fo) are elevated. To test this hypothesis, we conducted a perceptual experiment where 78 heterosexual males rated sexual attractiveness of 9 female voice samples, recorded at menstrual, follicular and luteal phases of the ...
Sorting hidden patterns in nanoparticle performance for glioblastoma using mach...
Basso, João; Mendes, Maria; Silva, Jessica; Cova, Tânia; Luque-Michel, Edurne; Jorge, Andreia F.; Grijalvo, Santiago; Gonçalves, Lídia; Eritja, RamonCationic compounds have been described to readily penetrate cell membranes. Assigning positive charge to nanosystems, e.g. lipid nanoparticles, has been identified as a key feature to promote electrostatic binding and design ligand-based constructs for tumour targeting. However, their intrinsic high cytotoxicity has hampered their biomedical application. This paper seeks to establish which cationic compounds an...
Biomimeting ultra-small lipid nanoconstructs for glioblastoma treatment: A comp...
Mendes, Maria; Basso, João; Silva, Jessica; Cova, Tânia; Sousa, João; Pais, Alberto; Vitorino, CarlaUltra-small nanostructured lipid carriers (usNLCs) are stable, biocompatible and biodegradable colloidal systems, claiming a broad set of advanced features suitable for cancer drug delivery. To unleash their potential in glioblastoma research and therapy, we have developed an usNLC prototype able to co-encapsulate atorvastatin calcium and curcumin, as repurposed drugs previously screened from molecular dynamics...
Hierarchical design of hyaluronic acid-peptide constructs for glioblastoma targ...
Mendes, Maria; Cova, Tânia; Basso, João; Ramos, M. Luísa; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, CarlaThe main bottleneck of glioblastoma still relies on the existence of the blood brain-blood brain tumor dual barrier, along with the lack of therapy specificity. The present work deals with the question of whether (and how) different targeting hyaluronic acid (HA)-peptide [c(RGDfK) and/or H7K(R2)2] moieties hierarchically interact with each other, to ensure a unique entity with specificity to glioblastoma. A dua...
Hierarchical design of hyaluronic acid-peptide constructs for glioblastoma targ...
Mendes, Maria; Cova, Tânia; Basso, João; Ramos, M. Luísa; Vitorino, Rui; Sousa, João; Pais, Alberto; Vitorino, CarlaThe main bottleneck of glioblastoma still relies on the existence of the blood brain-blood brain tumor dual barrier, along with the lack of therapy specificity. The present work deals with the question of whether (and how) different targeting hyaluronic acid (HA)-peptide [c(RGDfK) and/or H7K(R2)2] moieties hierarchically interact with each other, to ensure a unique entity with specificity to glioblastoma. A dua...
Hydrogel-Based Drug Delivery Nanosystems for the Treatment of Brain Tumors
Basso, João; Miranda, Ana; Nunes, Sandra; Cova, Tânia; Sousa, João; Vitorino, Carla; Pais, AlbertoChemotherapy is commonly associated with limited effectiveness and unwanted side effects in normal cells and tissues, due to the lack of specificity of therapeutic agents to cancer cells when systemically administered. In brain tumors, the existence of both physiological barriers that protect tumor cells and complex resistance mechanisms to anticancer drugs are additional obstacles that hamper a successful cour...