10 documents found, page 1 of 1
Maternal heart exhibits metabolic and redox adaptations post-uncomplicated preg...
Tocantins, Carolina; Martins, João D.; Rodrigues, Óscar M; Grilo, Luís F.; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, PedroPregnancy may be a challenging period for the maternal systems and has been regarded as a stress test, as imperceptible/mild dysfunctions eventually present may be exacerbated during this period. The cardiovascular system is no exception, and several morphological and functional adaptations accompanying pregnancy have been described. However, long-term pregnancy-induced cardiac molecular alterations remain high...
Gestational Exercise Antagonises the Impact of Maternal High-Fat High-Sucrose D...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Oliveira, Paulo J.; Ascensão, António; Magalhães, JoséMaternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are relevant modulators of the intrauterine environment, increasing the risk of liver metabolic alterations in mothers and offspring. In contrast, as a non-pharmacological approach against metabolic disorders, exercise is highly recommended in GDM treatment. We analysed whether gestational exercise (GE) protects mothers from diet-in...
Metabolic mitochondrial alterations prevail in the female rat heart 8 weeks aft...
Tocantins, Carolina; Martins, João D; Rodrigues, Óscar M; Grilo, Luís F; Diniz, Mariana S.; Stevanovic-Silva, Jelena; Beleza, Jorge; Coxito, PedroThe consumption of high-caloric diets strongly contributes to the development of non-communicable diseases (NCDs), including cardiovascular disease, the leading cause of mortality worldwide. Exercise (along with diet intervention) is one of the primary non-pharmacological approaches to promote a healthier lifestyle and counteract the rampant prevalence of NCDs. The present study evaluated the effects of exercis...
Fit mothers for a healthy future: Breaking the intergenerational cycle of non-a...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Magalhães, JoséSPECIAL ISSUE: 'FOIEGRAS-Bioenergetic Remodelling in the Pathophysiology and Treatment of Non-Alcoholic Fatty Liver Disease'.
Gestational Exercise Increases Male Offspring’s Maximal Workload Capacity Early...
Beleza, Jorge; Stevanović-Silva, Jelena; Coxito, Pedro; Rocha, Hugo; Santos, Paulo; Ascensão, António; Ramon Torrella, Joan; Magalhães, JoséMothers' antenatal strategies to improve the intrauterine environment can positively decrease pregnancy-derived intercurrences. By challenging the mother-fetus unit, gestational exercise (GE) favorably modulates deleterious stimuli, such as high-fat, high-sucrose (HFHS) diet-induced adverse consequences for offspring. We aimed to analyze whether GE alters maternal HFHS-consumption effects on male offspring's ma...
Exercise performed during pregnancy positively modulates liver metabolism and p...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, Rossana; Fernandes, RuiGestational diabetes mellitus (GDM) is associated with a high-risk for metabolic complications in offspring. However, exercise is recognized as a non-pharmacological strategy against metabolic disorders and is recommended in GDM treatment. This study aimed to investigate whether gestational exercise (GE) could modulate maternal high-fat high-sucrose (HFHS) diet-related hepatic metabolic and mitochondrial outcom...
Preventive and Therapeutic Potential of Physical Exercise in Neurodegenerative ...
Marques-Aleixo, Inês; Beleza, Jorge; Sampaio, Arnaldina; Stevanović, Jelena; Coxito, Pedro; Gonçalves, Inês; Ascensão, António; Magalhães, JoséSignificance: The prevalence and incidence of age-related neurodegenerative diseases (NDDs) tend to increase along with the enhanced average of the world life expectancy. NDDs are a major cause of morbidity and disability, affecting the health care, social and economic systems with a significant impact. Critical Issues and Recent Advances: Despite the worldwide burden of NDDs and the ongoing research efforts to...
Maternal high-fat high-sucrose diet and gestational exercise modulate hepatic f...
Stevanović-Silva, Jelena; Beleza, Jorge; Coxito, Pedro; Pereira, Susana; Rocha, Hugo; Gaspar, Tiago Bordeira; Gärtner, Fátima; Correia, RossanaMaternal high-caloric nutrition and related gestational diabetes mellitus (GDM) are associated with a high-risk for developing metabolic complications later in life and in their offspring. In contrast, exercise is recognized as a non-pharmacological strategy against metabolic dysfunctions associated to lifestyle disorders. Therefore, we investigated whether gestational exercise delays the development of metabol...
Building-up fit muscles for the future: Transgenerational programming of skelet...
Beleza, Jorge; Stevanović-Silva, Jelena; Coxito, Pedro; Costa, Rui Carlos; Ascensão, António; Torrella, Joan Ramon; Magalhães, José'Special issue - In Utero and Early Life Programming of Aging and Disease'. Skeletal muscle (SM) adaptations to physical exercise (PE) have been extensively studied due, not only to the relevance of its in situ plasticity, but also to the SM endocrine-like effects in noncontractile tissues, such as brain, liver or adipocytes. Regular PE has been considered a pleiotropic nonpharmacological strategy to prevent an...
Bile acids are toxic for isolated cardiac mitochondria
Ferreira, Manuela; Coxito, Pedro; Sardão, Vilma; Palmeira, Carlos; Oliveira, PauloCholestasis and other liver diseases may affect the heart through the toxic effects of the retained bile acids on cardiac mitochondria, which could explain the origin of hepatic-derived cardiomyopathies. The objective of this work was to test the hypothesis that bile acids are toxic to heart mitochondria for concentrations that are relevant for cholestasis. Heart mitochondria were isolated from rat and subjecte...