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A designed cyclic analogue of gomesin has potent activity against Staphylococcu...
Dias, Susana; Pinto, Sandra; Silva-Herdade, Ana S.; Cheneval, Olivier; Craik, David J; Coutinho, Ana; Castanho, Miguel A. R. B.; Henriques, Sónia T.Background: Infections caused by bacterial biofilms are very difficult to treat. The use of currently approved antibiotics even at high dosages often fails, making the treatment of these infections very challenging. Novel antimicrobial agents that use distinct mechanisms of action are urgently needed. Objectives: To explore the use of [G1K,K8R]cGm, a designed cyclic analogue of the antimicrobial peptide gomesin...
Date: 2022
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Origin: Repositório da Universidade de Lisboa