16 documents found, page 1 of 2
4-Chloroethcathinone (4-CEC) in a single binge exposure triggers immediate and ...
De Mello-Sampayo, C.; Leitão, M.; Gamito, C.; Brites, D.; Lopes, A. T.Background: Synthetic cathinones (SC) are β-keto analogues of amphetamine. They usually produce short-lived stimulant effects, which trigger higher desire of re-dosing with potential risk of overdosing. Its consumption occurs frequently in the form of multiple administration during a single exposure-event (binge), mostly by young party attendees. Adolescence is a critical time of brain development, and any disr...
Polyphenols journey through blood-brain barrier towards neuronal protection
Figueira, I.; Garcia, G.; Pimpão, R.; Terrasso, C.; Costa, I.; Almeida, A.; Tavares, L.; Pais, T.; Pinto, Paula; Ventura, M.; Filipe, A.; McDougall, G.Age-related complications such as neurodegenerative disorders are increasing and remain cureless. The possibility of altering the progression or the development of these multifactorial diseases through diet is an emerging and attractive approach with increasing experimental support. We examined the potential of known bioavailable phenolic sulfates, arising from colonic metabolism of berries, to infuence hallmar...
Bioaccessible (poly)phenol metabolites from raspberry protect neural cells from...
Garcia, G.; Nanni, S.; Figueira, I.; Ivanov, I.; McDougall, G. J.; Stewart, D.; Ferreira, R. B.; Pinto, Paula; Silva, R. F. M.; Brites, D.Neuroinflammation is an integral part of the neurodegeneration process inherent to several aging dysfunctions. Within the central nervous system, microglia are the effective immune cells, responsible for neuroinflammatory responses. In this study, raspberries were subjected to in vitro digestion simulation to obtain the components that result from the gastrointestinal (GI) conditions, which would be bioaccessib...
Exploring Multidrug resistance-associated Protein 1 (MRP1) expression during Ne...
Falcao, A.; Torrado, E.; Fernandes, A.; Abranches, E.; Bekman, E.; Brito, A.; Silva, R. F. M.; Henrique, D.; Brites, D.
A NOVEL DELETION IN UDP-GLUCURONOSYLTRANSFERASE GENE IN A PATIENT PRESENTING CR...
Elisio, C.; Vieira, E.; Lopes, A. I.; Saldanha, M. J.; Brites, D.; Dos Santos, R.
OLIGODENDROCYTE PROGENITOR CELL SUSCEPTIBILITY TO INJURY BY UNCONJUGATED BILIRUBIN
Barateiro, A.; Leitao, Silva S.; Vaz, A. R.; Fernandes, A.; Brites, D.
Inhibition of nitric oxide production prevents apoptotic features mediated by i...
Vaz, A. R.; Silva, S. Leitao; Barateiro, A.; Fernandes, A.; Falcao, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.
Implications of nitrosative stress in apoptotic cascades mediated by pro-inflam...
Vaz, A. R.; Leitão Silva, S.; Barateiro, A.; Fernandes, A.; Falcão, A. S.; Silva, R. F. M.; Brito, M. A.; Brites, D.The inflammatory response is essential for survival in response to tissue injury or infection, but it can also cause neuronal damage [1]. In fact, pro-inflammatory cytokines, as well as nitric oxide (NO), are known as mediators of neuronal apoptosis [2,3]. Although apoptosis occurs physiologically in the brain during the period of the growth spurt, an increase in the number of neurons undergoing apoptosis may p...
Biological risks for neurological abnormalities associated with hyperbilirubinemia
Brites, D.; Fernandes, A.; Falcao, A. S.; Gordo, A. C.; Silva, R. F. M.; Brito, M. A.Unconjugated bilirubin (UCB) injury to glial cells leads to the secretion of glutamate and elicits a typical inflammatory response. Release of pro-inflammatory cytokines may influence gliogenesis and neurogenesis, and lead to deficits in learning and memo. - Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Portugal. - The authors are grateful to the Fundacao para a Ciencia e a Tecnologia (FCT), Lisbon, Por...
BILIRUBIN-INDUCED CHANGES AT NEURONAL CYTOSKELETAL DYNAMICS
Fernandes, A.; Coutinho, E.; Lanier, L. M.; Brites, D.