19 documents found, page 1 of 2

Whole genome sequencing identifies novel mutations in malaria parasites resista...

Funding Information: The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. The authors would like to acknowledge i. the Portuguese “Fundação para a Ciência e Tecnologia (FCT)” for funds to GHTM – UID/Multi/04413/2020, LA-REAL-LA/P/0117/2020 and for funds to Pedro Ferreira`s project ref. PTDC/SAU-PAR/2766/2021 and ii. the Brazilian funding age...

Mutation in the 26S proteasome regulatory subunit rpn2 gene in Plasmodium falci...

The author(s) declare financial support was received for the research, authorship, and/or publication of this article. Financial support was provided by grants from Portuguese National funds, through the Foundation for Science and Technology (FCT) -project UIDB/50026/2020 (DOI 10.54499/UIDB/50026/2020), UIDP/50026/2020 (DOI 10.54499/UIDP/50026/2020) and LA/P/0050/2020 (DOI 10.54499/LA/P/0050/2020), PTDC/SAU-PAR...

Evaluation of the Polyphenolic Composition and Bioactivities of Three Native Ca...

Funding Information: The authors are grateful to the Foundation for Science and Technology (FCT, Portugal) for financial support through national funds FCT/MCTES (PIDDAC) to CIMO (UIDB/00690/2020 and UIDP/00690/2020) and SusTEC (LA/P/0007/2021); National funding by FCT, P.I., through the individual scientific employment program contract for L. Barros, A. Fernandes, M.I. Dias and C. Pereira. This research was fu...

On the contribution of the rodent model Plasmodium chabaudi for understanding t...

Copyright © 2022. Published by Elsevier B.V.; Malaria is a devastating disease that still claims over half a million lives every year, mostly in sub-Saharan Africa. One of the main barriers to malaria control is the evolution and propagation of drug-resistant mutant parasites. Knowing the genes and respective mutations responsible for drug resistance facilitates the design of drugs with novel modes of action an...

Efflux pump inhibitors as a promising adjunct therapy against drug resistant tu...

Introduction: In 2018, an estimated 377,000 people developed multidrug-resistant tuberculosis (MDR-TB), urging for new effective treatments. In the last years, it has been accepted that efflux pumps play an important role in the evolution of drug resistance. Strategies are required to mitigate the consequences of the activity of efflux pumps. Areas covered: Based upon the literature available in PubMed, up to F...

In silico epitope mapping and experimental evaluation of the Merozoite Adhesive...

BACKGROUND: Technical limitations for culturing the human malaria parasite Plasmodium vivax have impaired the discovery of vaccine candidates, challenging the malaria eradication agenda. The immunogenicity of the M2 domain of the Merozoite Adhesive Erythrocytic Binding Protein (MAEBL) antigen cloned from the Plasmodium yoelii murine parasite, has been previously demonstrated. RESULTS: Detailed epitope mapping o...

Outbreak of human malaria caused by Plasmodium simium in the Atlantic Forest in...

Background: Malaria was eliminated from southern and southeastern Brazil over 50 years ago. However, an increasing number of autochthonous episodes attributed to Plasmodium vivax have recently been reported from the Atlantic Forest region of Rio de Janeiro state. As the P vivax-like non-human primate malaria parasite species Plasmodium simium is locally enzootic, we performed a molecular epidemiological investi...

Amazonian plant natural products

Plasmodium falciparum and P. vivax malaria parasites are now resistant, or showing signs of resistance, to most drugs used in therapy. Novel chemical entities that exhibit new mechanisms of antiplasmodial action are needed. New antimalarials that block transmission of Plasmodium spp. from humans to Anopheles mosquito vectors are key to malaria eradication efforts. Although P. vivax causes a considerable number ...

Artemisinin resistance in rodent malaria - Mutation in the AP2 adaptor μ-chain ...

Background: The control of malaria, caused by Plasmodium falciparum, is hampered by the relentless evolution of drug resistance. Because artemisinin derivatives are now used in the most effective anti-malarial therapy, resistance to artemisinin would be catastrophic. Indeed, studies suggest that artemisinin resistance has already appeared in natural infections. Understanding the mechanisms of resistance would h...

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