Background Few studies examine the relationship between socioeconomic factors and trends in mortality in highincome European countries. Due to the lack of regional-level data, most recent studies on social inequality in Portugal do not investigate regional differences. This study analyses time trends and regional disparities in the evolution of perinatal mortality (PMR) and infant mortality (IMR) associated wit...
After the successful launch of the 2nd KLAARA Conference – Conference on Accessible Lan guage and Communication, the 3rd KLAARA Conference is designed in a partnership between FENACERCI and the Polytechnic of Leiria through the School of Education and Social Sciences. The multidisciplinary KLAARA conference is the venue for researchers interested in the study of language and accessible communication. The confer...
O desenvolvimento de uma úlcera crónica nos membros inferiores vai influenciar a estabilidade da pessoa e, por conseguinte, a saúde da própria família, exigindo para os mesmos a aquisição de estratégias de coping eficazes de modo a minimizar o impacto das suas repercussões, com vista ao equilíbrio. Atendendo à cronicidade da úlcera, o papel do enfermeiro é fulcral para facilitar a adaptação às mudanças daí deco...
Made available in DSpace on 2022-04-28T16:56:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2022-03-07. Added 1 bitstream(s) on 2022-04-28T17:11:39Z : No. of bitstreams: 1 S2326-45942022000100403.pdf: 359609 bytes, checksum: 9a96c9d8e48e9f815b8a239d82b6a57a (MD5); Research on the genetics, epidemiology, and clinical manifestations of Fabry disease (FD) has increased significantly in recent years. However,...
Chemotherapy administration is one of the most common practices on the Oncology Units and, as any nursing practice, it requires the existence of a solid knowledge. It is fundamental, to ensure a safe practice, for the nurse to have knowledge and understanding about the chemotherapy drugs, how to administer them, their side effects, the potential risks for himself and for the patient and how to act in case of ex...
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We previously reported that prenylated chalcone 2 (PC2), the O-prenyl derivative (2) of 2'-hydroxy-3,4,4',5,6'-pentamethoxychalcone (1), induced cytotoxicity of tumor cells via disruption of p53-MDM2 interaction. However, the cellular changes through which PC2 exerts its cytotoxic activity and its antitumor potential, remain to be addressed. In the present work, we aimed to (i) characterize the effect of PC2 on...
De acordo com o estado da arte acerca da estrutura do serviço de urgência dos hospitais, da especificidade da sala de emergência, da situação crítica vivenciada pela pessoa e sua família, das barreiras à comunicação em contexto de situação crítica e tendo em conta as competências do enfermeiro especialista em Enfermagem Médico-Cirúrgica, foi identificada como necessidade a presença de um suporte descritivo do q...
Este estudo visa analisar as competências de exploração de carreira em adultos reclusos, em função de variáveis sociodemográficas. Nesse sentido, apresenta-se uma investigação com 58 reclusos, de um estabelecimento prisional de Portugal. Os resultados indicam que os reclusos se encontram numa situação, em geral, favorável à exploração vocacional. Verificam-se ainda diferenças estatisticamente significativas no ...
Abnormal chromosome number, or aneuploidy, is a common feature of human solid tumors, including oral cancer. Deregulated spindle assembly checkpoint (SAC) is thought as one of the mechanisms that drive aneuploidy. In normal cells, SAC prevents anaphase onset until all chromosomes are correctly aligned at the metaphase plate thereby ensuring genomic stability. Significantly, the activity of this checkpoint is co...