9 documents found, page 1 of 1
An RPC-PET brain scanner demonstrator: first results
Fonte, Paulo; Lopes, Luís; Alves, Rui; Carolino, Nuno; Crespo, Paulo; Couceiro, Miguel; Cunha, Orlando; Dias, Nuno; Ferreira, Nuno C.; Fetal, SuseteWe present first results from a Positron Emission Tomography (PET) scanner demonstrator based on Resistive Plate Chambers and specialized for brain imaging. The device features a 30 cm wide cubic field-of-view and each detector comprises 40 gas gaps with 3D location of the interaction point of the photon. Besides other imagery, we show that the reconstructed image resolution, as evaluated by a hot-rod phantom, ...
Optimization of multiple coils immersed in a conducting liquid for half-hemisph...
Sousa, Sonia C. P.; Almeida, Jorge; Cavaleiro Miranda, Pedro; Salvador, Ricardo; Silvestre, Joao; Simoes, Hugo; Crespo, PauloTranscranial magnetic stimulation (TMS) was proposed in 1985. Nevertheless, its wider use in the treatment of several neurologic diseases has been hindered by its inability to stimulate deep-brain regions. This is mainly due to the physical limiting effect arising from the presence of surface discontinuities, particularly between the scalp and air. Here, we present the optimization of a system of large multiple...
Low dose irradiation of three-dimensional cell cultures has an acute effect on ...
Costa, Pedro; Lemos, Joana; Cunha, Lídia; Genésio, Paula; Ponte, Fernanda; Costa, Paulo S.; Crespo, Paulo; Metello, Luís F.Low doses of ionizing radiation are not yet consistently studied and documented. In such context, more advanced and complex biological models should be applied to obtain relevant data. Recognizing several known limitations and difficulties of the current monolayer cellular models, as well as the increasing difficulties to use advanced biological models, our group has been developing advanced biological alternat...
The acute effect on three-dimensional cellular proliferation rate of low dose i...
Costa, Pedro; Lemos, Joana; Cunha, Lídia; Neuparth, Teresa; Genésio, Paula; Ponte, Fernanda; Costa, Paulo; Crespo, Paulo; Metello, LuísLow doses of ionizing radiation are not yet consistently studied and documented. In such context, more advanced and complex biological models should be applied to obtain relevant data. Known limitations of monolayer cellular models and ever increasing difficulties to use some biological models, lead to develop advanced biological models, namely three-dimensional cell cultures.
Assessing radiobiological effects of diagnostic level doses of ionizing radiati...
Lemos, Joana; Costa, Pedro; Cunha, Lídia; Carvalho, António Paulo; Neuparth, Teresa; Genésio, Paula; Ponte, Fernanda; Costa, Paulo; Crespo, PauloThis paper relates with the application of zebrafish – Danio rerio – to the study of radiobiological effects of medical diagnostic level – low doses – of ionizing radiation. In recent years, the use of zebrafish has grown considerably, pointing more and more as a very interesting model in biomedical research, essentially because of the level of homology shared with the human genome, complemented by an easy and ...
Modern Radiobiology: Study of Ionizing Radiation Biological Effects using Three...
Costa, Pedro; Lemos, Joana; Cunha, Lídia; Carvalho, António P.; Vasconcelos, Vítor; Genésio, Paula; Ponte, Fernanda; Costa, Paulo S.; Crespo, PauloBiological effects of high doses of ionizing radiation are reasonably well studied and documented. Nevertheless, there is a clear lack of information and/or evidence concerning biological effects of Low Doses, namely at medical imaging levels, as those characterizing Nuclear Medicine and Radiology typical environments. Our group has being involved in the in vitro study of these low dose radiobiological effects....
Assessing Radiobiological Effects of Low Doses of Ionizing Radiation on Zebrafi...
Lemos, Joana; Costa, Pedro; Cunha, Lídia; Campos, Alexandre; Carvalho, António Paulo; Vasconcelos, Vítor; Genésio, Paula; Ponte, Fernanda; Costa, PauloAim: This paper relates with a specific task from a larger research project oriented to the development and application of the Zebrafish – Danio rerio – to the study of radiobiological effects of medical diagnostic level – low doses – of ionizing radiation.
Evaluation of Radiobiological Effects in Three Distinct Biological Models
Lemos, Joana; Costa, Pedro; Cunha, Lídia; Carvalho, António Paulo; Vasconcelos, Vítor; Genésio, Paula; Ponte, Fernanda; Costa, Paulo; Crespo, PauloThe present work aims to share the process of development of advanced biological models to study radiobiological effects. Recognizing several known limitations and difficulties of the current monolayer cellular models, as well as the increasing difficulties to use advanced biological models, our group has been developing advanced biological alternative models, namely three- dimensional cell cultures and a less ...
Developing advanced biological models to study effects of low doses of ionizing...
Lemos, Joana; Costa, Pedro; Cunha, Lídia; Carvalho, António P.; Vasconcelos, Vítor; Silva, Regina; Fernandes, Sílvia; Santos, João; Cunha, MicaelaThe biological effects of high doses of ionizing radiation are reasonably well studied and documented. Nevertheless, there is a clear lack of evidence concerning biological effects of Low Doses, namely at medical imaging levels, as those characterizing Nuclear Medicine and Radiology typical environments. Recognizing limitations and translational difficulties of the actual monolayer cellular models, our group ha...